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dc.contributor.authorSun, Jing
dc.contributor.authorBuys, Nicholas
dc.date.accessioned2021-06-14T00:01:39Z
dc.date.available2021-06-14T00:01:39Z
dc.date.issued2021
dc.identifier.issn2297-055X
dc.identifier.doi10.3389/fcvm.2021.614117
dc.identifier.urihttp://hdl.handle.net/10072/405096
dc.description.abstractBackground High blood urea nitrogen (BUN) is associated with adverse outcomes in patients with cardiac disease risks. However, no study has explored whether BUN can predict the risk of cardiovascular disease (CVD) in the healthy older population. This study aims to explore the incidence and risk factors of CVD among a healthy older population community in China. Design and Methods: This study was designed as a cohort study with a four-year follow-up. We recruited 5,000 older people among 137,625 residents of the Gaohang community. In the baseline, subjects were asked to participate in medical screening and biological tests, and answered survey questions. During the follow-up period (2014–2017), the researchers regularly tested the subjects’ indicators and assessment scales. We monitored the occurrence of CVD and explored the relationship between BUN and CVD via a Cox regression analysis. Results: During the follow-up, subjects were newly diagnosed with CVD including heart failure (HF), heart disease events, atrial fibrillation, diabetes, hypertension, metabolic syndrome and kidney disease. The Cox regression analysis found an association between baseline BUN and incident CVD in female subjects, with higher BUN associated with increased risk of AF in females and kidney disease in both male and females. No association was found between BUN and CVD in male subjects. Conclusions: Current results indicate that BUN is a valuable predictive biomarker of CVD. A higher BUN level (> 13.51 mg/dL) is associated with an increased occurrence of HF but a decreased occurrence of diabetes and metabolic symptoms in normal older females.
dc.description.peerreviewedYes
dc.description.sponsorshipGriffith University
dc.languageEnglish
dc.publisherFrontiers Media
dc.relation.ispartofpagefrom1614117
dc.relation.ispartofjournalFrontiers in Cardiovascular Medicine
dc.relation.ispartofvolume8
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320101
dc.subject.fieldofresearchcode3201
dc.subject.keywordsblood urea nitrogen
dc.subject.keywordscardiovascular disease
dc.subject.keywordsolder populations
dc.subject.keywordsprediction
dc.subject.keywordsrisk factors
dc.titleThe Value of Blood Urea Nitrogen in the Prediction of Risks of Cardiovascular Disease in an Older Population
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSun, J; Buys, N, The Value of Blood Urea Nitrogen in the Prediction of Risks of Cardiovascular Disease in an Older Population, Frontiers in Cardiovascular Medicine, 2021, 8, pp. 614117
dcterms.dateAccepted2021-04-26
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-06-13T23:27:08Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 Lan, Zheng, Zhou, Wu, Buys, Liu, Sun and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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gro.griffith.authorBuys, Nicholas J.


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