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  • The Neuroprotective Effects of Isosteviol against Focal Cerebral Ischemia Injury Induced by Middle Cerebral Artery Occlusion in Rats

    Author(s)
    Xu, D
    Du, W
    Zhao, L
    Davey, AK
    Wang, J
    Griffith University Author(s)
    Davey, Andrew
    Year published
    2008
    Metadata
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    Abstract
    Occlusion of a cerebral artery impairs blood flow leading to neuronal death. Reperfusion of the tissue is associated with inflammation, increased reactive oxygen species, necrosis and apoptosis. Hence, damage to the brain will continue even after the blood flow is restored. Isosteviol has been demonstrated to have protective effects against ischemia-reperfusion (IR) injury in the rat heart and the current study was undertaken to determine whether it is also effective in preventing IR injury in the brain. Rats were divided into six groups: a sham-operation control group and 5 IR groups that were pre-treated with either ...
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    Occlusion of a cerebral artery impairs blood flow leading to neuronal death. Reperfusion of the tissue is associated with inflammation, increased reactive oxygen species, necrosis and apoptosis. Hence, damage to the brain will continue even after the blood flow is restored. Isosteviol has been demonstrated to have protective effects against ischemia-reperfusion (IR) injury in the rat heart and the current study was undertaken to determine whether it is also effective in preventing IR injury in the brain. Rats were divided into six groups: a sham-operation control group and 5 IR groups that were pre-treated with either isosteviol 5 mg竧-1, 10 mg竧-1, 20 mg竧-1, nimodipine 5 mg竧-1, or saline. Cerebral ischemia was induced for 2 hours. Twenty-two hours after re-perfusion the rats were assessed for neurobehavioral deficit, infarct volume, histological changes, and malondialdehyde, superoxide dismutase (SOD), Bcl-2 and NF-?B levels in brain tissue. Pre-treatment with isosteviol reduced infarct volume, ameliorated cell death and infiltration of neutrocytes, improved neuro-locomotor activity, increased SOD activity, induced Bcl-2, suppressed lipid superoxidation and the expression of NF-?B, and therefore retarded necrosis and apoptosis of neurons and inflammation. These positive effects were dose-dependent with an isosteviol dose of 20 mg竧-1, thus being as effective as nimodipine.
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    Journal Title
    Planta Medica
    Volume
    74
    Issue
    8
    DOI
    https://doi.org/10.1055/s-2008-1074557
    Subject
    Basic Pharmacology
    Plant Biology
    Complementary and Alternative Medicine
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/40512
    Collection
    • Journal articles

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