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dc.contributor.authorKowitz, Monique
dc.contributor.authorChakradeo, Katrina
dc.contributor.authorHennessey, Ashleigh
dc.contributor.authorWolski, Penny
dc.date.accessioned2021-06-14T22:45:24Z
dc.date.available2021-06-14T22:45:24Z
dc.date.issued2021
dc.identifier.issn1444-0903en_US
dc.identifier.urihttp://hdl.handle.net/10072/405123
dc.description.abstractAim: Antisynthetase syndrome (anti-SS) is a rare systemic autoimmune disease characterised by autoantibodies against aminoacyl-tRNA synthetases manifesting as one or more components of the classic triad: interstitial lung disease (ILD), arthritis and myositis. Whilst it is well-recognised that autoimmune rheumatological disorders can contribute to multiple pregnancy complications, little is known about how anti-SS itself affects pregnancy outcomes. This report aims to identify pregnancy complications associated with anti-SS and their targeted management. Method: Described is the case of a 26-year-old pregnant woman with anti-SS who had a complicated pregnancy on a background of multiple prior miscarriages. Her pregnancy was complicated by a disease flare at 23 weeks' gestation, placental dysfunction identified on obstetric ultrasound at 24+4 weeks' gestation, and subsequent extremely premature delivery at 24+6 weeks' gestation. Her placenta demonstrated features consistent with maternal vascular malperfusion (MVM) and borderline massive perivillous fibrin deposition (MPVFD) with a normal karyotype. A review of all published cases of anti-SS syndrome in pregnancy was performed. Their outcomes were compared and factors contributing to pregnancy complications, as well as potential management strategies, were identified. Result: Disease activity and the presence of ILD, anti-Ro/SSA and anti-La/SSB antibodies and antiphospholipid syndrome were identified as key factors leading to poor pregnancy outcomes. Additionally, it was hypothesised that autoimmunity and inflammation in anti-SS may contribute to placental dysfunction in the form of MVM and MPVFD which can lead to miscarriage, stillbirth, intrauterine growth restriction and prematurity. Conclusion: Overall, this case highlights the complexity of managing anti-SS in pregnancy, and explores potential pregnancy complications associated with anti-SS and their management. These include pre-pregnancy counselling and optimisation of disease control prior to conception, regular monitoring for both maternal and fetal complications, specific medications such as low-dose aspirin and low-molecular-weight heparin to reduce the risk of placental dysfunction, and a multidisciplinary team approach.en_US
dc.languageEnglishen_US
dc.publisherWileyen_US
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1111/imj.15302en_US
dc.relation.ispartofconferencenameAustralian Rheumatology Association Annual Scientific Meeting with the Rheumatology Health Professionals Associationen_US
dc.relation.ispartofconferencetitleInternal Medicine Journalen_US
dc.relation.ispartofdatefrom2021-05-21
dc.relation.ispartofdateto2021-05-23
dc.relation.ispartoflocationSydney, Australiaen_US
dc.relation.ispartofpagefrom38en_US
dc.relation.ispartofpageto38en_US
dc.relation.ispartofissueS2en_US
dc.relation.ispartofvolume51en_US
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematologyen_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.subject.fieldofresearchcode1102en_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.fieldofresearchcode1117en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsMedicine, General & Internalen_US
dc.subject.keywordsGeneral & Internal Medicineen_US
dc.titleAntisynthetase syndrome in pregnancy: a case report and review of the literatureen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conferences (Extract Paper)en_US
dcterms.bibliographicCitationKowitz, M; Chakradeo, K; Hennessey, A; Wolski, P, Antisynthetase syndrome in pregnancy: a case report and review of the literature, Internal Medicine Journal, 2021, 51, pp. 38-38en_US
dc.date.updated2021-06-13T22:36:11Z
gro.hasfulltextNo Full Text
gro.griffith.authorChakradeo, Katrina K.


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