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  • Ferritinophagy and ferroptosis in the management of metabolic diseases

    Author(s)
    Ajoolabady, A
    Aslkhodapasandhokmabad, H
    Libby, P
    Tuomilehto, J
    Lip, GYH
    Penninger, JM
    Richardson, DR
    Tang, D
    Zhou, H
    Wang, S
    Klionsky, DJ
    Kroemer, G
    Ren, J
    Griffith University Author(s)
    Richardson, Des R.
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases, denoting the likely therapeutic promises for targeting ferroptosis in the preservation of human health. Ferritinophagy, a selective form of autophagy, contributes to the initiation of ferroptosis through degradation of ferritin, which triggers labile iron overload (IO), lipid peroxidation, membrane damage, and cell death. In this review, we will delineate the role of ferritinophagy ...
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    Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases, denoting the likely therapeutic promises for targeting ferroptosis in the preservation of human health. Ferritinophagy, a selective form of autophagy, contributes to the initiation of ferroptosis through degradation of ferritin, which triggers labile iron overload (IO), lipid peroxidation, membrane damage, and cell death. In this review, we will delineate the role of ferritinophagy in ferroptosis, and its underlying regulatory mechanisms, to unveil the therapeutic value of ferritinophagy as a target in the combat of ferroptosis to manage metabolic diseases.
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    Journal Title
    Trends in Endocrinology and Metabolism
    Volume
    32
    Issue
    7
    DOI
    https://doi.org/10.1016/j.tem.2021.04.010
    Subject
    Paediatrics
    Reproductive medicine
    Clinical sciences
    ferritinophagy
    ferroptosis
    iron overload
    lipid peroxidation
    metabolic diseases
    Publication URI
    http://hdl.handle.net/10072/405135
    Collection
    • Journal articles

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