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dc.contributor.authorNahar, Nusrat
dc.contributor.authorTurni, Conny
dc.contributor.authorTram, Greg
dc.contributor.authorBlackall, Patrick J
dc.contributor.authorAtack, John M
dc.date.accessioned2021-06-21T02:08:02Z
dc.date.available2021-06-21T02:08:02Z
dc.date.issued2021
dc.identifier.issn0065-2911
dc.identifier.doi10.1016/bs.ampbs.2020.12.001
dc.identifier.urihttp://hdl.handle.net/10072/405225
dc.description.abstractActinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is responsible for high economic losses in swine herds across the globe. Pleuropneumonia is characterized by severe respiratory distress and high mortality. The knowledge about the interaction between bacterium and host within the porcine respiratory tract has improved significantly in recent years. A. pleuropneumoniae expresses multiple virulence factors, which are required for colonization, immune clearance, and tissue damage. Although vaccines are used to protect swine herds against A. pleuropneumoniae infection, they do not offer complete coverage, and often only protect against the serovar, or serovars, used to prepare the vaccine. This review will summarize the role of individual A. pleuropneumoniae virulence factors that are required during key stages of pathogenesis and disease progression, and highlight progress made toward developing effective and broadly protective vaccines against an organism of great importance to global agriculture and food production.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom179
dc.relation.ispartofpageto216
dc.relation.ispartofjournalAdvances in Microbial Physiology
dc.relation.ispartofvolume78
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode30
dc.titleActinobacillus pleuropneumoniae: The molecular determinants of virulence and pathogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNahar, N; Turni, C; Tram, G; Blackall, PJ; Atack, JM, Actinobacillus pleuropneumoniae: The molecular determinants of virulence and pathogenesis, Advances in Microbial Physiology, 2021, 78, pp. 179-216
dc.date.updated2021-06-21T01:58:38Z
gro.hasfulltextNo Full Text
gro.griffith.authorTram, Greg C.
gro.griffith.authorAtack, John M.


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