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dc.contributor.authorZhang, Jiayu
dc.contributor.authorDuy, Thanh Nguyen
dc.contributor.authorPierens, Gregory K
dc.contributor.authorCock, Ian
dc.contributor.authorFeng, Yunjiang
dc.date.accessioned2021-06-25T06:02:43Z
dc.date.available2021-06-25T06:02:43Z
dc.date.issued2021
dc.identifier.issn1478-6419
dc.identifier.doi10.1080/14786419.2021.1923710
dc.identifier.urihttp://hdl.handle.net/10072/405236
dc.description.abstractA new picrotoxane terpenoid glycoside, austrobuxusin N (1), together with four known compounds, austrobuxusin A-D (2-5), were isolated from the leaves of the Australian endemic plant Austrobuxus swainii (Beuzev. & C.T. White) Airy Shaw. The chemical structure of 1 was elucidated by 1D- and 2D-NMR spectroscopy, along with MS data. The sugar moiety in 1 was determined to be β-D-glucose by acid hydrolysis and subsequent comparison of its specific rotation with that of standard. The relative configuration of the aglycone was assigned by ROESY NMR experiment and density functional theory (DFT) calculation of NMR data coupled with DP4 analysis. Cytotoxicity test revealed that compound 1 exhibited 71% inhibition against Caco-2 cell line at the concentration of 166 µM.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherTaylor & Francis Group
dc.relation.ispartofjournalNatural Product Research
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsChemistry, Applied
dc.subject.keywordsChemistry, Medicinal
dc.titleAustrobuxusin N, a new picrotoxane terpenoid glycoside, from the Australian endemic plant Austrobuxus swainii (Beuzev. & CT White) Airy Shaw
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhang, J; Nguyen, DT; Pierens, GK; Cock, I; Feng, Y, Austrobuxusin N, a new picrotoxane terpenoid glycoside, from the Australian endemic plant Austrobuxus swainii (Beuzev. & CT White) Airy Shaw, Natural Product Research, 2021
dc.date.updated2021-06-21T04:01:35Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyrightThis is an Author's Accepted Manuscript of an article published in Natural Product Research, 18 May 2021, copyright Taylor & Francis, available online at: https://doi.org/10.1080/14786419.2021.1923710
gro.hasfulltextFull Text
gro.griffith.authorFeng, Yun J.
gro.griffith.authorCock, Ian E.
gro.griffith.authorNguyen, Thanh


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