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dc.contributor.authorJin, Shujuan
dc.contributor.authorZhan, Jian
dc.contributor.authorZhou, Yaoqi
dc.date.accessioned2021-06-21T05:50:45Z
dc.date.available2021-06-21T05:50:45Z
dc.date.issued2021
dc.identifier.issn0301-4851
dc.identifier.doi10.1007/s11033-021-06476-w
dc.identifier.urihttp://hdl.handle.net/10072/405240
dc.description.abstractArgonaute proteins are highly conserved and widely expressed in almost all organisms. They not only play a critical role in the biogenesis of small RNAs but also defend against invading nucleic acids via small RNA or DNA-mediated gene silencing pathways. One functional mechanism of Argonaute proteins is acting as a nucleic-acid-guided endonuclease, which can cleave targets complementary to DNA or RNA guides. The cleavage then leads to translational silencing directly or indirectly by recruiting additional silencing proteins. Here, we summarized the latest research progress in structural and biological studies of Argonaute proteins and pointed out their potential applications in the field of gene editing.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalMolecular Biology Reports
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode0601
dc.subject.keywordsArgonaute
dc.subject.keywordsEndonuclease
dc.subject.keywordsGuide
dc.subject.keywordsMID domain
dc.subject.keywordsPIWI domain
dc.titleArgonaute proteins: structures and their endonuclease activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationJin, S; Zhan, J; Zhou, Y, Argonaute proteins: structures and their endonuclease activity, Molecular Biology Reports, 2021
dcterms.dateAccepted2021-06-05
dc.date.updated2021-06-21T01:00:07Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorZhou, Yaoqi
gro.griffith.authorZhan, Jian


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