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dc.contributor.authorProtani, Melinda M
dc.contributor.authorJordan, Susan J
dc.contributor.authorKendall, Bradley J
dc.contributor.authorSiskind, Dan
dc.contributor.authorLawrence, David
dc.contributor.authorSara, Grant
dc.contributor.authorBrophy, Lisa
dc.contributor.authorKisely, Steve
dc.date.accessioned2021-06-21T06:32:11Z
dc.date.available2021-06-21T06:32:11Z
dc.date.issued2021
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2020-044737
dc.identifier.urihttp://hdl.handle.net/10072/405248
dc.description.abstractINTRODUCTION: Colorectal cancer (CRC) mortality is significantly higher in those with severe mental illness (SMI) compared with the general population, despite similar incidence rates, suggesting that barriers to optimal screening and cancer care may contribute to disparities in CRC mortality in those with SMI. This study aims to compare participation in Australia's National Bowel Cancer Screening Programme (NBCSP) in those with SMI and those in the general population. We will also investigate treatment pathways after diagnosis to determine whether treatment variations could explain differences in CRC mortality. METHODS AND ANALYSIS: We will undertake a retrospective cohort study of Australians using linked administrative data to assess differences in screening and cancer care between those with and without SMI, aged 50-74 years on or after 1 January 2006. People with SMI will be defined using antipsychotic medication prescription data. The comparison group will be people enrolled in Medicare (Australia's universal healthcare system) who have not been prescribed antipsychotic medication. Data on outcomes (NBCSP participation, follow-up colonoscopy, CRC incidence and CRC-cause and all-cause mortality) and confounders will be obtained from national-based and state-based administrative health datasets. All people in New South Wales, aged 50-74 with a new diagnosis of CRC on or after 1 January 2006, will be ascertained to examine stage at diagnosis and cancer treatment in those with and without SMI. Poisson regression will be used to calculate incidence rates and rate ratios for each outcome. ETHICS AND DISSEMINATION: Ethics approval has been obtained from the University of Queensland Human Research Ethics Committee, the Australian Institute of Health and Welfare Ethics Committee and data custodians from every Australian State/Territory. Findings will be disseminated via publications in peer-reviewed journals and presented at appropriate conferences. TRIAL REGISTRATION NUMBER: ACTRN12620000781943.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherBMJ
dc.relation.ispartofpagefrome044737
dc.relation.ispartofissue6
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume11
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.subject.keywordsepidemiology
dc.subject.keywordsgastrointestinal tumours
dc.subject.keywordsschizophrenia & psychotic disorders
dc.titleColorectal cancer Outcomes in people with Severe Mental Illness Cohort (COSMIC): a protocol for an Australian retrospective cohort using linked administrative data.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationProtani, MM; Jordan, SJ; Kendall, BJ; Siskind, D; Lawrence, D; Sara, G; Brophy, L; Kisely, S, Colorectal cancer Outcomes in people with Severe Mental Illness Cohort (COSMIC): a protocol for an Australian retrospective cohort using linked administrative data., BMJ Open, 2021, 11 (6), pp. e044737
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2021-06-21T01:36:10Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Author(s) (or their employer(s)) 2021. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
gro.hasfulltextFull Text
gro.griffith.authorKisely, Steve R.


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