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dc.contributor.authorKahlyar, Htar
dc.contributor.authorRoxby, David
dc.contributor.authorBadrick, Tony
dc.contributor.authorVanniasinkam, Thiru
dc.description.abstractBackground and Objectives: Accurate and regular monitoring of anti-A and anti-B titres pre- and post-transplantation plays a crucial role in the clinical management of patients receiving ABO-incompatible renal transplants. There is no standardized protocol or an external quality assurance program (EQA) currently available for this testing in Australia. The aim of this study was to investigate the diversity of techniques, test platforms and reagents that were currently in use in various laboratories with the aim of developing an EQA. Materials and Methods: An online survey was sent to the participants enrolled with the Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) to assess their interest in participation in the pilot study. A total of 24 participants who expressed interest were sent the group O plasma, A1, A2 and B cells to perform ABO titration using their own methods. Results: Participants reported a wide range of titre results, from 8 to 1024 for the anti-A titre using A1 cells, from 2 to 128 for anti-A titre using A2 cells and from neat to 32 for anti-B titre using B cells. Conclusion: There was a wide variation in titre results between and within different technologies. These findings demonstrate the need for an ABO titration EQA. Development of a standard technique and participation in an EQA program should, over time, reduce variation and enable transferrable results across testing centres, which will assist in consistent clinical interpretation and better outcomes for patients.en_US
dc.relation.ispartofjournalVox Sanguinisen_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchMedical Physiologyen_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsexternal quality assuranceen_US
dc.titleChallenges in antibody titration for ABO-incompatible renal transplantationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationKahlyar, H; Roxby, D; Badrick, T; Vanniasinkam, T, Challenges in antibody titration for ABO-incompatible renal transplantation, Vox Sanguinis, 2021en_US
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.en_US
gro.hasfulltextNo Full Text
gro.griffith.authorBadrick, Tony C.

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