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dc.contributor.authorPei, Peng
dc.contributor.authorChen, Ying
dc.contributor.authorSun, Caixia
dc.contributor.authorFan, Yong
dc.contributor.authorYang, Yanmin
dc.contributor.authorLiu, Xuan
dc.contributor.authorLu, Lingfei
dc.contributor.authorZhao, Mengyao
dc.contributor.authorZhang, Hongxin
dc.contributor.authorZhao, Dongyuan
dc.contributor.authorLiu, Xiaogang
dc.contributor.authorZhang, Fan
dc.date.accessioned2021-06-23T06:42:59Z
dc.date.available2021-06-23T06:42:59Z
dc.date.issued2021
dc.identifier.issn1748-3387
dc.identifier.doi10.1038/s41565-021-00922-3
dc.identifier.urihttp://hdl.handle.net/10072/405302
dc.description.abstractPersistent luminescence is not affected by background autofluorescence, and thus holds the promise of high-contrast bioimaging. However, at present, persistent luminescent materials for in vivo imaging are mainly bulk crystals characterized by a non-uniform size and morphology, inaccessible core-shell structures and short emission wavelengths. Here we report a series of X-ray-activated, lanthanide-doped nanoparticles with an extended emission lifetime in the second near-infrared window (NIR-II, 1,000-1,700 nm). Core-shell engineering enables a tunable NIR-II persistent luminescence, which outperforms NIR-II fluorescence in signal-to-noise ratios and the accuracy of in vivo multiplexed encoding and multilevel encryption, as well as in resolving mouse abdominal vessels, tumours and ureters in deep tissue (~2-4 mm), with up to fourfold higher signal-to-noise ratios and a threefold greater sharpness. These rationally designed nanoparticles also allow the high-contrast multiplexed imaging of viscera and multimodal NIR-II persistent luminescence-magnetic resonance-positron emission tomography imaging of murine tumours.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalNature Nanotechnology
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchcode4018
dc.titleX-ray-activated persistent luminescence nanomaterials for NIR-II imaging
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPei, P; Chen, Y; Sun, C; Fan, Y; Yang, Y; Liu, X; Lu, L; Zhao, M; Zhang, H; Zhao, D; Liu, X; Zhang, F, X-ray-activated persistent luminescence nanomaterials for NIR-II imaging, Nature Nanotechnology, 2021
dcterms.dateAccepted2021-04-30
dc.date.updated2021-06-23T01:48:10Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorZhao, Dongyuan


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