dc.contributor.author | Pei, Peng | |
dc.contributor.author | Chen, Ying | |
dc.contributor.author | Sun, Caixia | |
dc.contributor.author | Fan, Yong | |
dc.contributor.author | Yang, Yanmin | |
dc.contributor.author | Liu, Xuan | |
dc.contributor.author | Lu, Lingfei | |
dc.contributor.author | Zhao, Mengyao | |
dc.contributor.author | Zhang, Hongxin | |
dc.contributor.author | Zhao, Dongyuan | |
dc.contributor.author | Liu, Xiaogang | |
dc.contributor.author | Zhang, Fan | |
dc.date.accessioned | 2021-06-23T06:42:59Z | |
dc.date.available | 2021-06-23T06:42:59Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1748-3387 | |
dc.identifier.doi | 10.1038/s41565-021-00922-3 | |
dc.identifier.uri | http://hdl.handle.net/10072/405302 | |
dc.description.abstract | Persistent luminescence is not affected by background autofluorescence, and thus holds the promise of high-contrast bioimaging. However, at present, persistent luminescent materials for in vivo imaging are mainly bulk crystals characterized by a non-uniform size and morphology, inaccessible core-shell structures and short emission wavelengths. Here we report a series of X-ray-activated, lanthanide-doped nanoparticles with an extended emission lifetime in the second near-infrared window (NIR-II, 1,000-1,700 nm). Core-shell engineering enables a tunable NIR-II persistent luminescence, which outperforms NIR-II fluorescence in signal-to-noise ratios and the accuracy of in vivo multiplexed encoding and multilevel encryption, as well as in resolving mouse abdominal vessels, tumours and ureters in deep tissue (~2-4 mm), with up to fourfold higher signal-to-noise ratios and a threefold greater sharpness. These rationally designed nanoparticles also allow the high-contrast multiplexed imaging of viscera and multimodal NIR-II persistent luminescence-magnetic resonance-positron emission tomography imaging of murine tumours. | |
dc.description.peerreviewed | Yes | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartofjournal | Nature Nanotechnology | |
dc.subject.fieldofresearch | Nanotechnology | |
dc.subject.fieldofresearchcode | 4018 | |
dc.title | X-ray-activated persistent luminescence nanomaterials for NIR-II imaging | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Pei, P; Chen, Y; Sun, C; Fan, Y; Yang, Y; Liu, X; Lu, L; Zhao, M; Zhang, H; Zhao, D; Liu, X; Zhang, F, X-ray-activated persistent luminescence nanomaterials for NIR-II imaging, Nature Nanotechnology, 2021 | |
dcterms.dateAccepted | 2021-04-30 | |
dc.date.updated | 2021-06-23T01:48:10Z | |
gro.description.notepublic | This publication has been entered in Griffith Research Online as an advanced online version. | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Zhao, Dongyuan | |