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  • Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

    Author(s)
    Battle, Andrew R
    Valenzuela, Stella M
    Mechler, Adam
    Nichols, Ryan J
    Praporski, Slavica
    di Maio, Isabelle L
    Islam, Hedoyetul
    Cirard-Egrot, Agnes P
    Cornell, Bruce A
    Prashar, Jog
    Caruso, Frank
    Martin, Lisandra L
    Martin, Donald K
    Griffith University Author(s)
    Battle, Andrew
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically ...
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    The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.
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    Journal Title
    Advanced Functional Materials
    Volume
    19
    Issue
    2
    DOI
    https://doi.org/10.1002/adfm.200800483
    Subject
    Physical sciences
    Chemical sciences
    Engineering
    Publication URI
    http://hdl.handle.net/10072/40531
    Collection
    • Journal articles

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