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dc.contributor.authorvan Hal, Sebastiaan J
dc.contributor.authorEspedido, Bjorn A
dc.contributor.authorCoombs, Geoffrey W
dc.contributor.authorHowden, Benjamin P
dc.contributor.authorKorman, Tony M
dc.contributor.authorNimmo, Graeme R
dc.contributor.authorGosbell, Iain B
dc.contributor.authorJensen, Slade O
dc.date.accessioned2021-06-24T06:15:39Z
dc.date.available2021-06-24T06:15:39Z
dc.date.issued2017
dc.identifier.issn0305-7453
dc.identifier.doi10.1093/jac/dkw539
dc.identifier.urihttp://hdl.handle.net/10072/405351
dc.description.abstractObjectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.relation.ispartofpagefrom998
dc.relation.ispartofpageto1001
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Antimicrobial Chemotherapy
dc.relation.ispartofvolume72
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode3214
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsInfectious Diseases
dc.subject.keywordsPharmacology & Pharmacy
dc.titlePolyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationvan Hal, SJ; Espedido, BA; Coombs, GW; Howden, BP; Korman, TM; Nimmo, GR; Gosbell, IB; Jensen, SO, Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia, Journal of Antimicrobial Chemotherapy, 2017, 72 (4), pp. 998-1001
dcterms.dateAccepted2016-11-21
dc.date.updated2021-06-24T05:52:13Z
gro.hasfulltextNo Full Text
gro.griffith.authorNimmo, Graeme R.


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