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  • Facile synthesis of uniform virus-like mesoporous silica nanoparticles for enhanced cellular internalization

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    Zhao165609-Published.pdf (5.616Mb)
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    Version of Record (VoR)
    Author(s)
    Wang, Wenxing
    Wang, Peiyuan
    Tang, Xueting
    Elzatahry, Ahmed A
    Wang, Shuwen
    Al-Dahyan, Daifallah
    Zhao, Mengyao
    Yao, Chi
    Hung, Chin-Te
    Zhu, Xiaohang
    Zhao, Tiancong
    Li, Xiaomin
    Zhang, Fan
    Zhao, Dongyuan
    Griffith University Author(s)
    Zhao, Dongyuan
    Year published
    2017
    Metadata
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    Abstract
    The low-efficiency cellular uptake property of current nanoparticles greatly restricts their application in the biomedical field. Herein, we demonstrate that novel virus-like mesoporous silica nanoparticles can easily be synthesized, showing greatly superior cellular uptake property. The unique virus-like mesoporous silica nanoparticles with a spiky tubular rough surface have been successfully synthesized via a novel single-micelle epitaxial growth approach in a low-concentration-surfactant oil/water biphase system. The virus-like nanoparticles' rough surface morphology results mainly from the mesoporous silica nanotubes ...
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    The low-efficiency cellular uptake property of current nanoparticles greatly restricts their application in the biomedical field. Herein, we demonstrate that novel virus-like mesoporous silica nanoparticles can easily be synthesized, showing greatly superior cellular uptake property. The unique virus-like mesoporous silica nanoparticles with a spiky tubular rough surface have been successfully synthesized via a novel single-micelle epitaxial growth approach in a low-concentration-surfactant oil/water biphase system. The virus-like nanoparticles' rough surface morphology results mainly from the mesoporous silica nanotubes spontaneously grown via an epitaxial growth process. The obtained nanoparticles show uniform particle size and excellent monodispersity. The structural parameters of the nanoparticles can be well tuned with controllable core diameter (60-160 nm), tubular length (6-70 nm), and outer diameter (6-10 nm). Thanks to the biomimetic morphology, the virus-like nanoparticles show greatly superior cellular uptake property (invading living cells in large quantities within few minutes, <5 min), unique internalization pathways, and extended blood circulation duration (t = 2.16 h), which is much longer than that of conventional mesoporous silica nanoparticles (0.45 h). Furthermore, our epitaxial growth strategy can be applied to fabricate various virus-like mesoporous core-shell structures, paving the way toward designed synthesis of virus-like nanocomposites for biomedicine applications. 1/2
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    Journal Title
    ACS Central Science
    Volume
    3
    Issue
    8
    DOI
    https://doi.org/10.1021/acscentsci.7b00257
    Copyright Statement
    © 2017 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
    Subject
    Chemical sciences
    Science & Technology
    Physical Sciences
    Chemistry, Multidisciplinary
    Chemistry
    DRUG-DELIVERY
    Publication URI
    http://hdl.handle.net/10072/405380
    Collection
    • Journal articles

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