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  • Progress towards a vaccine for Streptococcus pyogenes

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    69591_1.pdf (2.430Mb)
    Author(s)
    Batzloff, Michael
    McMillan, David
    Pandey, Manisha
    Griffith University Author(s)
    Pandey, Manisha
    Year published
    2009
    Metadata
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    Abstract
    Infection with Streptococcus pyogenes (group A streptococcus, GAS) can lead to rheumatic fever (RF) and rheumatic heart disease (RHD), which are significant health concerns in the Indigenous populations of developed countries, including Australian Aboriginal people. The global burden of GAS diseases had been recently reviewed 1 and multiple studies have demonstrated the high burden of these diseases in Australia 2-4. RF and RHD are autoimmune type diseases, in which T-cells and antibodies targeting the bacteria may also cross-react with human tissues, therefore rendering a whole cell vaccine impractical.Infection with Streptococcus pyogenes (group A streptococcus, GAS) can lead to rheumatic fever (RF) and rheumatic heart disease (RHD), which are significant health concerns in the Indigenous populations of developed countries, including Australian Aboriginal people. The global burden of GAS diseases had been recently reviewed 1 and multiple studies have demonstrated the high burden of these diseases in Australia 2-4. RF and RHD are autoimmune type diseases, in which T-cells and antibodies targeting the bacteria may also cross-react with human tissues, therefore rendering a whole cell vaccine impractical.
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    Journal Title
    Microbiology Australia
    Volume
    30
    Issue
    5
    Publisher URI
    http://www.theasm.org.au/publications/microbiology-australia
    Copyright Statement
    © 2009 ASM. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Medical Bacteriology
    Biochemistry and Cell Biology
    Microbiology
    Publication URI
    http://hdl.handle.net/10072/40542
    Collection
    • Journal articles

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    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander