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dc.contributor.authorMahendiran, Dharmasivam
dc.contributor.authorKumar, Raju Senthil
dc.contributor.authorViswanathan, Vijayan
dc.contributor.authorVelmurugan, Devadasan
dc.contributor.authorRahiman, Aziz Kalilur
dc.date.accessioned2021-06-30T01:51:40Z
dc.date.available2021-06-30T01:51:40Z
dc.date.issued2017
dc.identifier.issn0949-8257
dc.identifier.doi10.1007/s00775-017-1488-6
dc.identifier.urihttp://hdl.handle.net/10072/405470
dc.description.abstractAbstract: The bis(4′-(4-tolyl)-2,2′:6′,2″-terpyridine)copper(II) complex [Cu(ttpy) ]Cl was synthesized and authenticated by single crystal analysis, which shows distorted octahedral geometry around copper(II) ion. The crystal packing is stabilized by C–H inter and intramolecular interactions. The complex was found to be lipophilic as determined by shake-flask method. In vitro cytotoxicity of the complex was tested against Ehrlich ascites carcinoma (EAC) and L6 myotube cell lines. The complex exhibit potent cytotoxicity with respect to the commercially available anticancer drug cisplatin. Hoechst 33258, AO/EB and PI (flow cytometry) staining methods suggest that the complex can induce apoptosis in EAC cells. Cell cycle analyses also support the induced apoptosis. Cellular uptake studies revealed that the complex can go into the cytoplasm and accumulate in the cell nuclei. The complex induces EAC cell apoptosis through a ROS-mediated mitochondrial pathway by activating caspase 3 and caspase 7 and regulates the Bcl-2 family proteins. In vivo study of the complex was validated against the animal tumor growth (EAC) cell in Swiss albino mice. Graphical abstract: The bis(4′-(4-tolyl)-2,2′:6′,2″-terpyridine)copper(II) complex induces EAC cell apoptosis through a ROS-mediated mitochondrial pathway and significantly reduced the body weight and solid tumor volume in Swiss albino mice.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSPRINGER
dc.relation.ispartofpagefrom1109
dc.relation.ispartofpageto1122
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Biological Inorganic Chemistry
dc.relation.ispartofvolume22
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsChemistry, Inorganic & Nuclear
dc.titleIn vitro and in vivo anti-proliferative evaluation of bis(4'-(4-tolyl)-2,2':6',2aEuro(3)-terpyridine)copper(II) complex against Ehrlich ascites carcinoma tumors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMahendiran, D; Kumar, RS; Viswanathan, V; Velmurugan, D; Rahiman, AK, In vitro and in vivo anti-proliferative evaluation of bis(4'-(4-tolyl)-2,2':6',2aEuro(3)-terpyridine)copper(II) complex against Ehrlich ascites carcinoma tumors, Journal of Biological Inorganic Chemistry, 2017, 22 (7), pp. 1109-1122
dcterms.dateAccepted2017-08-20
dc.date.updated2021-06-30T01:29:22Z
gro.hasfulltextNo Full Text
gro.griffith.authorDharmasivam, Mahendiran


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