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dc.contributor.authorPyne, JH
dc.contributor.authorMyint, E
dc.contributor.authorBarr, EM
dc.contributor.authorClark, SP
dc.contributor.authorDavid, M
dc.contributor.authorNa, R
dc.description.abstractBackground: Squamous cell carcinoma (SCC) may present with or without the feature of acantholysis. Methods: Investigate invasive acantholytic SCC by microscopic maximum tumor surface diameter, depth of invasion, grade of differentiation, perineural invasion (PNI) and percentage of acantholysis. Assess recurrence following excision. Results: A total of 1658 consecutive invasive SCC cases were examined, comprising 4.9% acantholytic SCC. Median tumor microscopic maximum diameter was 8 mm for acantholytic SCC and 7.3 mm for non-acantholytic SCC. Median tumor invasion depth was 1.0 mm for acantholytic SCC and 1.5 mm for non-acantholytic SCC. Well, moderate and poor differentiation were not significantly different between acantholytic SCC and non-acantholytic SCC. One PNI case was found in 82 acantholytic SCC cases. A total of 77 acantholytic SCC cases were followed up over a median 25 months finding histologic proven recurrence at three acantholytic SCC excision sites. Conclusions: Acantholytic SCC were more likely to be located on head sites with less median depth than non-acantholytic SCC. Increasing percentage of acantholysis within acantholytic SCC was not associated with a shift towards poor differentiation. Histologic margins of 1.2 mm may adequately excise small acantholytic SCC. No recorded deaths, low PNI and low recurrence rates suggests acantholytic SCC is low-risk.
dc.relation.ispartofjournalJournal of Cutaneous Pathology
dc.subject.fieldofresearchClinical sciences
dc.subject.keywordsacantholytic squamous cell carcinoma
dc.subject.keywordsgrade of differentiation
dc.subject.keywordsperineural invasion
dc.subject.keywordssurgical margins
dc.subject.keywordssurgical recurrence rate
dc.titleAcantholytic invasive squamous cell carcinoma: tumor diameter, invasion depth, grade of differentiation, surgical margins, perineural invasion, recurrence and death rate
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPyne, JH; Myint, E; Barr, EM; Clark, SP; David, M; Na, R, Acantholytic invasive squamous cell carcinoma: tumor diameter, invasion depth, grade of differentiation, surgical margins, perineural invasion, recurrence and death rate, Journal of Cutaneous Pathology, 2017, 44 (4), pp. 320-327
gro.hasfulltextNo Full Text
gro.griffith.authorDavid, Michael

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