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dc.contributor.authorTang, KD
dc.contributor.authorMenezes, L
dc.contributor.authorBaeten, K
dc.contributor.authorWalsh, LJ
dc.contributor.authorWhitfield, BCS
dc.contributor.authorBatstone, MD
dc.contributor.authorKenny, L
dc.contributor.authorFrazer, IH
dc.contributor.authorScheper, GC
dc.contributor.authorPunyadeera, C
dc.date.accessioned2021-07-06T11:16:24Z
dc.date.available2021-07-06T11:16:24Z
dc.date.issued2020
dc.identifier.issn2218-273X
dc.identifier.doi10.3390/biom10020223
dc.identifier.urihttp://hdl.handle.net/10072/405720
dc.description.abstractThe role of human papillomavirus type 16 (HPV16) in oral potentially malignant disorders (OPMD) and oral cavity carcinoma (OC) is still under debate. We investigated HPV16 prevalence in unstimulated saliva, oral rinse samples, oral swabs and tumour biopsies collected from OPMD (n = 83) and OC (n = 106) patients. HPV16 genotype, viral load, physical status (episomal vs. integrated) and tumour p16INK4a expression were determined. Oral HPV16 prevalence was higher in OC than in OPMD, but this difference was not statistically significant (7.5% (8/106) versus 3.6% (3/83), odds ratio (OR): 2.18, 95% confidence interval (CI): 0.56, 8.48, p = 0.26). There was a significant association (p < 0.05) between oral HPV16 infection and heavy tobacco consumption. Real-time PCR results indicated that no integration events occurred in either OPMD or OC cases based on the HPV16 E2/E6 ratio. HPV16 positive OPMD and OC patients had similar HPV16 E2 and E6 viral loads. The inter-rater agreement between tumour p16INK4a expression and oral HPV16 infection was considered as fair (k = 0.361) for OC. Our data suggest that the involvement of HPV16 in oral carcinogenesis is limited.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherMDPI AG
dc.relation.ispartofpagefrom223
dc.relation.ispartofissue2
dc.relation.ispartofjournalBiomolecules
dc.relation.ispartofvolume10
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3211
dc.subject.keywordshuman papillomavirus
dc.subject.keywordsoral cavity cancer
dc.subject.keywordsoral potentially malignant disorder
dc.subject.keywordssaliva
dc.subject.keywordsviral load and HPV integration
dc.titleOral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTang, KD; Menezes, L; Baeten, K; Walsh, LJ; Whitfield, BCS; Batstone, MD; Kenny, L; Frazer, IH; Scheper, GC; Punyadeera, C, Oral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers, Biomolecules, 2020, 10 (2), pp. 223
dcterms.dateAccepted2020-01-30
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-07-05T21:55:06Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorPunyadeera, Chamindie


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