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dc.contributor.authorPoole, RL
dc.contributor.authorCurry, PDK
dc.contributor.authorMarcinkute, R
dc.contributor.authorBrewer, C
dc.contributor.authorComan, D
dc.contributor.authorHobson, E
dc.contributor.authorJohnson, D
dc.contributor.authorLynch, SA
dc.contributor.authorSaggar, A
dc.contributor.authorSearle, C
dc.contributor.authorScurr, I
dc.contributor.authorTurnpenny, PD
dc.contributor.authorVasudevan, P
dc.contributor.authorTatton-Brown, K
dc.description.abstractSmith-Kingsmore Syndrome (SKS) is a rare genetic syndrome associated with megalencephaly, a variable intellectual disability, autism spectrum disorder, and MTOR gain of function variants. Only 30 patients with MTOR missense variants are published, including 14 (47%) with the MTOR c.5395G>A p.(Glu1799Lys) variant. Limited phenotypic data impacts the quality of information delivered to families and the robustness of interpretation of novel MTOR missense variation. This study aims to improve our understanding of the SKS phenotype through the investigation of 16 further patients with the MTOR c.5395G>A p.(Glu1799Lys) variant. Through the careful phenotypic evaluation of these 16 patients and integration with data from 14 previously reported patients, we have defined major (100% patients) and frequent (>15%) SKS clinical characteristics and, using these data, proposed guidance for evidence-based management. In addition, in the absence of functional studies, we suggest that the combination of the SKS major clinical features of megalencephaly (where the head circumference is at least 3SD) and an intellectual disability with a de novo MTOR missense variant (absent from population databases) should be considered diagnostic for SKS.en_US
dc.relation.ispartofjournalAmerican Journal of Medical Genetics, Part Aen_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.titleDelineating the Smith-Kingsmore syndrome phenotype: Investigation of 16 patients with the MTOR c.5395G > A p.(Glu1799Lys) missense varianten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationPoole, RL; Curry, PDK; Marcinkute, R; Brewer, C; Coman, D; Hobson, E; Johnson, D; Lynch, SA; Saggar, A; Searle, C; Scurr, I; Turnpenny, PD; Vasudevan, P; Tatton-Brown, K, Delineating the Smith-Kingsmore syndrome phenotype: Investigation of 16 patients with the MTOR c.5395G > A p.(Glu1799Lys) missense variant, American Journal of Medical Genetics, Part A, 2021en_US
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.en_US
gro.hasfulltextNo Full Text
gro.griffith.authorComan, Dave J.

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