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dc.contributor.authorRahman, Sabbir T
dc.contributor.authorPandeya, Nirmala
dc.contributor.authorNeale, Rachel E
dc.contributor.authorMcLeod, Donald SA
dc.contributor.authorBaade, Peter D
dc.contributor.authorYoul, Philippa H
dc.contributor.authorAllison, Roger
dc.contributor.authorLeonard, Susan
dc.contributor.authorJordan, Susan J
dc.date.accessioned2021-07-08T06:05:38Z
dc.date.available2021-07-08T06:05:38Z
dc.date.issued2021
dc.identifier.issn0300-0664en_US
dc.identifier.doi10.1111/cen.14545en_US
dc.identifier.urihttp://hdl.handle.net/10072/405854
dc.description.abstractOBJECTIVE: Smoking has been associated with a reduced risk of thyroid cancer, but whether the association varies between higher- and lower-risk cancers remains unclear. We aimed to assess the association between smoking and risk of thyroid cancer overall as well as by tumour BRAF mutational status as a marker of potentially higher-risk cancer. DESIGN AND PATIENTS: We recruited 1013 people diagnosed with thyroid cancer and 1057 population controls frequency-matched on age and sex. METHODS: Multivariable logistic regression was used to assess the association overall and in analyses stratified by tumour characteristics. We used sensitivity analysis to assess the potential for selection bias. RESULTS: We found little evidence of an association with current smoking (odds ratio [OR] = 0.93; 95% confidence interval [CI]: 0.69-1.26; current vs. never smoking), but a higher number of pack-years of smoking was associated with a lower risk of thyroid cancer (OR = 0.75; 95% CI: 0.57-0.99; ≥20 pack-years vs. never). However, after correcting for potential selection bias, we observed a statistically significant inverse association between current smoking and risk of thyroid cancer (bias-corrected OR = 0.65; 95% CI: 0.51-0.83). Those with BRAF-positive cancers were less likely to be current smokers than those with BRAF-negative cancers (prevalence ratio: 0.79; 95% CI: 0.62-0.99). CONCLUSION: We found smoking was inversely related to thyroid cancer risk and, in particular, current smoking was associated with a reduced risk of potentially more aggressive BRAF-positive than the likely more indolent BRAF-negative papillary thyroid cancers.en_US
dc.description.peerreviewedYesen_US
dc.languageengen_US
dc.publisherWileyen_US
dc.relation.ispartofjournalClinical Endocrinologyen_US
dc.subject.fieldofresearchOncology and Carcinogenesisen_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchPaediatrics and Reproductive Medicineen_US
dc.subject.fieldofresearchcode1112en_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.fieldofresearchcode1114en_US
dc.subject.keywordsBRAF-mutationen_US
dc.subject.keywordsbias analysisen_US
dc.subject.keywordspopulation-based sampleen_US
dc.subject.keywordsthyroid canceren_US
dc.subject.keywordstobacco smokingen_US
dc.titleTobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationRahman, ST; Pandeya, N; Neale, RE; McLeod, DSA; Baade, PD; Youl, PH; Allison, R; Leonard, S; Jordan, SJ, Tobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes, Clinical Endocrinology, 2021en_US
dcterms.dateAccepted2021-06-06
dc.date.updated2021-07-08T04:30:08Z
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.en_US
gro.hasfulltextNo Full Text
gro.griffith.authorBaade, Peter D.


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