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dc.contributor.authorRahman, Sabbir T
dc.contributor.authorPandeya, Nirmala
dc.contributor.authorNeale, Rachel E
dc.contributor.authorMcLeod, Donald SA
dc.contributor.authorBaade, Peter D
dc.contributor.authorYoul, Philippa H
dc.contributor.authorAllison, Roger
dc.contributor.authorLeonard, Susan
dc.contributor.authorJordan, Susan J
dc.description.abstractOBJECTIVE: Smoking has been associated with a reduced risk of thyroid cancer, but whether the association varies between higher- and lower-risk cancers remains unclear. We aimed to assess the association between smoking and risk of thyroid cancer overall as well as by tumour BRAF mutational status as a marker of potentially higher-risk cancer. DESIGN AND PATIENTS: We recruited 1013 people diagnosed with thyroid cancer and 1057 population controls frequency-matched on age and sex. METHODS: Multivariable logistic regression was used to assess the association overall and in analyses stratified by tumour characteristics. We used sensitivity analysis to assess the potential for selection bias. RESULTS: We found little evidence of an association with current smoking (odds ratio [OR] = 0.93; 95% confidence interval [CI]: 0.69-1.26; current vs. never smoking), but a higher number of pack-years of smoking was associated with a lower risk of thyroid cancer (OR = 0.75; 95% CI: 0.57-0.99; ≥20 pack-years vs. never). However, after correcting for potential selection bias, we observed a statistically significant inverse association between current smoking and risk of thyroid cancer (bias-corrected OR = 0.65; 95% CI: 0.51-0.83). Those with BRAF-positive cancers were less likely to be current smokers than those with BRAF-negative cancers (prevalence ratio: 0.79; 95% CI: 0.62-0.99). CONCLUSION: We found smoking was inversely related to thyroid cancer risk and, in particular, current smoking was associated with a reduced risk of potentially more aggressive BRAF-positive than the likely more indolent BRAF-negative papillary thyroid cancers.
dc.relation.ispartofjournalClinical Endocrinology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchReproductive medicine
dc.subject.keywordsbias analysis
dc.subject.keywordspopulation-based sample
dc.subject.keywordsthyroid cancer
dc.subject.keywordstobacco smoking
dc.titleTobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRahman, ST; Pandeya, N; Neale, RE; McLeod, DSA; Baade, PD; Youl, PH; Allison, R; Leonard, S; Jordan, SJ, Tobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes, Clinical Endocrinology, 2021
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.hasfulltextNo Full Text
gro.griffith.authorBaade, Peter D.

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