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dc.contributor.authorCromer, Deborah
dc.contributor.authorGrimm, Andrew J
dc.contributor.authorSchlub, Timothy E
dc.contributor.authorMak, Johnson
dc.contributor.authorDavenport, Miles P
dc.date.accessioned2021-07-11T05:12:07Z
dc.date.available2021-07-11T05:12:07Z
dc.date.issued2016
dc.identifier.issn0269-9370
dc.identifier.doi10.1097/QAD.0000000000000936
dc.identifier.urihttp://hdl.handle.net/10072/405881
dc.description.abstractBackground: HIV recombination has been estimated in vitro using a variety of approaches, and shows a high rate of template switching per reverse transcription event. In-vivo studies of recombination generally measure the accumulation of recombinant strains over time, and thus do not directly estimate a comparable template switching rate. Method: To examine whether the estimated in-vitro template switching rate is representative of the rate that occurs during HIV infection in vivo, we adopted a novel approach, analysing single genome sequences from early founder viruses to study the in-vivo template switching rate in the env region of HIV. Results: We estimated the in-vivo per cycle template switching rate to be between 0.5 and 1.5/1000 nt, or approximately 5-14 recombination events over the length of the HIV genome. Conclusion: The in-vivo estimated template switching rate is close to the in-vitro estimated rate found in primary T lymphocytes but not macrophages, which is consistent with the majority of HIV infection occurring in T lymphocytes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofpagefrom185
dc.relation.ispartofpageto192
dc.relation.ispartofissue2
dc.relation.ispartofjournalAIDS
dc.relation.ispartofvolume30
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode52
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsImmunology
dc.subject.keywordsInfectious Diseases
dc.subject.keywordsVirology
dc.titleEstimating the in-vivo HIV template switching and recombination rate
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCromer, D; Grimm, AJ; Schlub, TE; Mak, J; Davenport, MP, Estimating the in-vivo HIV template switching and recombination rate, AIDS, 2016, 30 (2), pp. 185-192
dc.date.updated2021-07-11T05:02:30Z
gro.hasfulltextNo Full Text
gro.griffith.authorMak, Johnson


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