Show simple item record

dc.contributor.authorHolzapfel, Nina Pauline
dc.contributor.authorShokoohmand, Ali
dc.contributor.authorWagner, Ferdinand
dc.contributor.authorLandgraf, Marietta
dc.contributor.authorChamp, Simon
dc.contributor.authorHolzapfel, Boris Michael
dc.contributor.authorClements, Judith Ann
dc.contributor.authorHutmacher, Dietmar Werner
dc.contributor.authorLoessner, Daniela
dc.description.abstractMutagens like oxidants cause lesions in the DNA of ovarian and fallopian tube epithelial cells, resulting in neoplastic transformation. Reduced exposure of surface epithelia to oxidative stress may prevent the onset or reduce the growth of ovarian cancer. Lycopene is well-known for its excellent antioxidant properties. In this study, the potential of lycopene in the prevention and treatment of ovarian cancer was investigated using an intraperitoneal animal model. Lycopene prevention significantly reduced the metastatic load of ovarian cancer-bearing mice, whereas treatment of already established ovarian tumors with lycopene significantly diminished the tumor burden. Lycopene treatment synergistically enhanced anti-tumorigenic effects of paclitaxel and carboplatin. Immunostaining of tumor and metastatic tissues for Ki67 revealed that lycopene reduced the number of proliferating cancer cells. Lycopene decreased the expression of the ovarian cancer biomarker, CA125. The anti-metastatic and antiproliferative effects were accompanied by down-regulated expression of ITGA5, ITGB1, MMP9, FAK, ILK and EMT markers, decreased protein expression of integrin a5 and reduced activation of MAPK. These findings indicate that lycopene interferes with mechanisms involved in the development and progression of ovarian cancer and that its preventive and therapeutic use, combined with chemotherapeutics, reduces the tumor and metastatic burden of ovarian cancer in vivo.
dc.publisherE-Century Publishing Corporation
dc.relation.ispartofjournalAmerican Journal of Cancer Research
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsovarian cancer
dc.titleLycopene reduces ovarian tumor growth and intraperitoneal metastatic load
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHolzapfel, NP; Shokoohmand, A; Wagner, F; Landgraf, M; Champ, S; Holzapfel, BM; Clements, JA; Hutmacher, DW; Loessner, D, Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load, American Journal of Cancer Research, 2017, 7 (6), pp. 1322-1336
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.
gro.griffith.authorShokoohmand, Ali

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record