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dc.contributor.authorRay, Subarna
dc.contributor.authorAdelnia, Hossein
dc.contributor.authorTa, Hang Thu
dc.date.accessioned2021-07-13T06:24:05Z
dc.date.available2021-07-13T06:24:05Z
dc.date.issued2021
dc.identifier.issn2047-4830
dc.identifier.doi10.1039/d1bm00516b
dc.identifier.urihttp://hdl.handle.net/10072/405917
dc.description.abstractCollagen is an important protein in various biological functions such as providing elasticity and waterproofing to the skin, structural stability to the cells in connective tissues (e.g. tendons, and bone) as well as stabilisation of the atherosclerotic plaque. Collagen as a peptide with a peculiar triple helix structure is majorly composed of glycine, and proline amino acids and is synthesised by fibroblasts via intracellular and extracellular mechanisms. Collagen plays an important role in wound healing, bone repair and plaque build-up during atherosclerosis. Various factors such as interleukins, insulin‐like growth factor-I, nicotine, and glucose have shown to influence collagen synthesis. This paper provides an overview on the collagen structure, synthesis mechanisms, and the effective parameters on its stimulation. Poly-L-lactic acid as a well-known biocompatible and biodegradable polymer has proved to stimulate collagen synthesis in various physical forms. As such, in this review a special emphasis is put on the effects of poly-L-lactic acid as well as its mechanism of action on collagen synthesis.
dc.description.peerreviewedYes
dc.languageen
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofjournalBiomaterials Science
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3206
dc.titleCollagen and the Effect of Poly-L-lactic Acid based Materials on its Synthesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRay, S; Adelnia, H; Ta, HT, Collagen and the Effect of Poly-L-lactic Acid based Materials on its Synthesis, Biomaterials Science
dc.date.updated2021-07-10T09:30:16Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2021 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorTa, Hang
gro.griffith.authorAdelnia, Hossein


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