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dc.contributor.authorChua, TC
dc.contributor.authorMittal, A
dc.contributor.authorArena, J
dc.contributor.authorSheen, A
dc.contributor.authorGill, AJ
dc.contributor.authorSamra, JS
dc.date.accessioned2021-07-14T01:30:35Z
dc.date.available2021-07-14T01:30:35Z
dc.date.issued2017
dc.identifier.issn0002-9610en_US
dc.identifier.doi10.1016/j.amjsurg.2016.09.049en_US
dc.identifier.urihttp://hdl.handle.net/10072/405938
dc.description.abstractIntroduction: Distal cholangiocarcinoma remains a rare cancer associated with a dismal outcome. There is a lack of effective treatment options and where disease is amendable to resection, surgery affords the best potential for long-term survival. The aim of this study was to examine the survival outcomes and prognostic factors of patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma. Methods: Between January 2004 to May 2016, patients who had undergone pancreatoduodenectomy with histologically proven distal cholangiocarcinoma were identified. Clinicopathologic data and survival outcomes were reported. Results: Pancreatoduodenectomy alone was performed in 20 patients (71%) and eight patients (29%) required concomitant vascular resection. The major complication rate was 43% (n = 12). Nineteen patients (68%) had node positive disease. Eighteen patients (64%) had R0 resection. The median survival was 36 months (95%CI 9.7 to 63.8) and 5-year survival rate was 24%. Univariate analysis identified ASA (P < 0.001), tumor grade (P = 0.009) and margin status (P = 0.042) as prognostic factors associated with survival. Conclusion: Long-term survival may be achieved in selected patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma, especially in patients who achieved an R0 resection.en_US
dc.description.peerreviewedYesen_US
dc.languageengen_US
dc.publisherElsevieren_US
dc.relation.ispartofpagefrom1072en_US
dc.relation.ispartofpageto1076en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalThe American Journal of Surgeryen_US
dc.relation.ispartofvolume213en_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.keywordsBiliary tract canceren_US
dc.subject.keywordsCholangiocarcinomaen_US
dc.subject.keywordsCisplatinen_US
dc.subject.keywordsPancreatoduodenectomyen_US
dc.subject.keywordsSurgeryen_US
dc.titleResection margin influences survival after pancreatoduodenectomy for distal cholangiocarcinomaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationChua, TC; Mittal, A; Arena, J; Sheen, A; Gill, AJ; Samra, JS, Resection margin influences survival after pancreatoduodenectomy for distal cholangiocarcinoma, The American Journal of Surgery, 2017, 213 (6), pp. 1072-1076en_US
dcterms.dateAccepted2016-09-14
dc.date.updated2021-07-14T01:28:51Z
gro.hasfulltextNo Full Text
gro.griffith.authorChua, Terence


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