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dc.contributor.authorChua, TC
dc.contributor.authorPetrushnko, W
dc.contributor.authorMittal, A
dc.contributor.authorGill, AJ
dc.contributor.authorSamra, JS
dc.date.accessioned2021-07-15T01:41:56Z
dc.date.available2021-07-15T01:41:56Z
dc.date.issued2016
dc.identifier.issn1091-255X
dc.identifier.doi10.1007/s11605-016-3106-2
dc.identifier.urihttp://hdl.handle.net/10072/405980
dc.description.abstractBackground: The pancreas and peripancreatic region may be a site of metastasis from distant sites. Recent data suggest that pancreatic metastasectomy may achieve long-term survival. We seek to examine our experience with this metastasectomy by reporting the perioperative and survival outcomes. Methods: Patients undergoing resection of isolated pancreatic metastasis were identified from a prospective pancreatic surgical database at the Department of Gastrointestinal Surgery, North Shore campus of the University of Sydney between January 2004 and June 2015 and selected for retrospective review. Data on operative morbidity and mortality were reported. Survival analysis was performed using the Kaplan–Meier method. Results: Fifteen patients underwent pancreatic metastasectomy after a median disease-free interval of 63 months (range 0 to 199). Pancreatoduodenectomy was performed in six patients (40 %), distal pancreatectomy with or without splenectomy in three patients (20 %), and pancreatectomy with other visceral organ resection in six patients (40 %). Major complications occurred in six patients (40 %) without mortality. The median survival was 40 months (95 % CI 24.3 to 53.7), and 1-, 3-, and 5-year survival were 76, 48, and 31 % respectively. Cox proportional hazard model identified margin negative resection (hazard ratio (HR) 10.5; P = 0.044) as a predictor of improved survival. Conclusion: Long-term survival may be achieved in selected patients with pancreatic metastasis through pancreatic metastasectomy with acceptable morbidity. Selection of patients should be individualized and based on their primary disease origin, biological behavior of the tumor, resectability of the tumor, and the relative effectiveness of systemic or targeted therapies.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom1188
dc.relation.ispartofpageto1193
dc.relation.ispartofjournalJournal of Gastrointestinal Surgery
dc.relation.ispartofvolume20
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsChemotherapy
dc.subject.keywordsMetastasectomy
dc.subject.keywordsMetastasis
dc.subject.keywordsPancreas
dc.subject.keywordsPancreatoduodenectomy
dc.titlePancreatic Metastasectomy—an Analysis of Survival Outcomes and Prognostic Factors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChua, TC; Petrushnko, W; Mittal, A; Gill, AJ; Samra, JS, Pancreatic Metastasectomy—an Analysis of Survival Outcomes and Prognostic Factors, Journal of Gastrointestinal Surgery, 2016, 20, pp. 1188-1193
dcterms.dateAccepted2016-02-11
dc.date.updated2021-07-15T01:36:31Z
gro.hasfulltextNo Full Text
gro.griffith.authorChua, Terence


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