dc.contributor.author | Eviston, TJ | |
dc.contributor.author | Minaei, E | |
dc.contributor.author | Mueller, SA | |
dc.contributor.author | Ahmadi, N | |
dc.contributor.author | Ashford, B | |
dc.contributor.author | Clark, JR | |
dc.contributor.author | West, N | |
dc.contributor.author | Zhang, P | |
dc.contributor.author | Gupta, R | |
dc.contributor.author | Ranson, M | |
dc.date.accessioned | 2021-07-15T23:13:50Z | |
dc.date.available | 2021-07-15T23:13:50Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.doi | 10.1038/s41598-021-92335-4 | |
dc.identifier.uri | http://hdl.handle.net/10072/406021 | |
dc.description.abstract | Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expression analysis approach and constructs a tailored gene panel for sensitivity and specificity analysis. 45 cases of HNcSCC were stratified into three groups (Extensive, Focal and Non PNI) based on predefined clinicopathological criteria. Here we show HNcSCC with extensive PNI demonstrates significant up- and down-regulation of 144 genes associated with extracellular matrix interactions, epithelial to mesenchymal transition, cell adhesion, cellular motility, angiogenesis, and cellular differentiation. Gene expression of focal and non PNI cohorts were indistinguishable and were combined for further analyses. There is clinicopathological correlation between gene expression analysis findings and disease behaviour and a tailored panel of 10 genes was able to identify extensive PNI with 96% sensitivity and 95% specificity. | |
dc.description.peerreviewed | Yes | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartofpagefrom | 13192 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Scientific Reports | |
dc.relation.ispartofvolume | 11 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3211 | |
dc.title | Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Eviston, TJ; Minaei, E; Mueller, SA; Ahmadi, N; Ashford, B; Clark, JR; West, N; Zhang, P; Gupta, R; Ranson, M, Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma, Scientific Reports, 2021, 11 (1), pp. 13192 | |
dcterms.dateAccepted | 2021-05-24 | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2021-07-15T21:30:07Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | West, Nic P. | |
gro.griffith.author | Zhang, Ping | |