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dc.contributor.authorEviston, TJ
dc.contributor.authorMinaei, E
dc.contributor.authorMueller, SA
dc.contributor.authorAhmadi, N
dc.contributor.authorAshford, B
dc.contributor.authorClark, JR
dc.contributor.authorWest, N
dc.contributor.authorZhang, P
dc.contributor.authorGupta, R
dc.contributor.authorRanson, M
dc.date.accessioned2021-07-15T23:13:50Z
dc.date.available2021-07-15T23:13:50Z
dc.date.issued2021
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-021-92335-4
dc.identifier.urihttp://hdl.handle.net/10072/406021
dc.description.abstractPerineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expression analysis approach and constructs a tailored gene panel for sensitivity and specificity analysis. 45 cases of HNcSCC were stratified into three groups (Extensive, Focal and Non PNI) based on predefined clinicopathological criteria. Here we show HNcSCC with extensive PNI demonstrates significant up- and down-regulation of 144 genes associated with extracellular matrix interactions, epithelial to mesenchymal transition, cell adhesion, cellular motility, angiogenesis, and cellular differentiation. Gene expression of focal and non PNI cohorts were indistinguishable and were combined for further analyses. There is clinicopathological correlation between gene expression analysis findings and disease behaviour and a tailored panel of 10 genes was able to identify extensive PNI with 96% sensitivity and 95% specificity.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom13192
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume11
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3211
dc.titleGene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationEviston, TJ; Minaei, E; Mueller, SA; Ahmadi, N; Ashford, B; Clark, JR; West, N; Zhang, P; Gupta, R; Ranson, M, Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma, Scientific Reports, 2021, 11 (1), pp. 13192
dcterms.dateAccepted2021-05-24
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-07-15T21:30:07Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorWest, Nic P.
gro.griffith.authorZhang, Ping


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