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dc.contributor.authorSharma, Shayna
dc.contributor.authorMasud, Mostafa Kamal
dc.contributor.authorKaneti, Yusuf Valentino
dc.contributor.authorRewatkar, Prarthana
dc.contributor.authorKoradia, Aayushi
dc.contributor.authorHossain, Md Shahriar A
dc.contributor.authorYamauchi, Yusuke
dc.contributor.authorPopat, Amirali
dc.contributor.authorSalomon, Carlos
dc.description.abstractExtracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as natural carriers for drugs and biologics. However, the challenges associated with EVs isolation, heterogeneity, coexistence with homologous biomolecules, and lack of site-specific delivery, have impeded their potential. In recent years, the amalgamation of EVs with rationally engineered nanostructures has been proposed for achieving effective drug loading and site-specific delivery. With the advancement of nanotechnology and nanoarchitectonics, different nanostructures with tunable size, shapes, and surface properties can be integrated with EVs for drug loading, target binding, efficient delivery, and therapeutics. Such integration may enable improved cellular targeting and the protection of encapsulated drugs for enhanced and specific delivery to target cells. This review summarizes the recent development of nanostructure amalgamated EVs for drug delivery, therapeutics, and real-time monitoring of disease progression. With a specific focus on the exosomal cargo, diverse drug delivery system, and biomimetic nanostructures based on EVs for selective drug delivery, this review also chronicles the needs and challenges of EV-based biomimetic nanostructures and provides a future outlook on the strategies posed.
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsChemistry, Multidisciplinary
dc.subject.keywordsChemistry, Physical
dc.titleExtracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSharma, S; Masud, MK; Kaneti, YV; Rewatkar, P; Koradia, A; Hossain, MSA; Yamauchi, Y; Popat, A; Salomon, C, Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications, Small, 2021
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorMasud, Mostafa Kamal K.

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