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dc.contributor.authorChang, Hsien-Feng
dc.contributor.authorWu, Chang-Chieh
dc.contributor.authorSun, Chien-An
dc.contributor.authorChu, Chi-Ming
dc.contributor.authorLin, Fu-Gong
dc.contributor.authorHsieh, Jih-Fu
dc.contributor.authorHsu, Chih-Hsiung
dc.contributor.authorHuang, Chi-Hua
dc.contributor.authorYang, Tsan
dc.contributor.authorTsai, Yang-Ming
dc.contributor.authorKuan, Jen-Chun
dc.contributor.authorChou, Yu-Ching
dc.date.accessioned2021-07-19T23:46:10Z
dc.date.available2021-07-19T23:46:10Z
dc.date.issued2016
dc.identifier.issn1081-5589en_US
dc.identifier.doi10.1136/jim-2016-000086en_US
dc.identifier.urihttp://hdl.handle.net/10072/406146
dc.description.abstractAberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited. We examined DNA methylation in tumors and adjacent normal tissues from patients who underwent CRC surgical resection, and evaluated the interaction between cancer staging (advanced vs local) and DNA methylation to predict the prognosis of CRC. We recruited 132 patients with CRC from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select 3 tumor suppressor genes involved in carcinogenesis pathways. ORs and 95% CIs were computed using logistic regression analyses while adjusting for potential covariates. Advanced cancer stage was correlated with cancer recurrence (OR 7.22, 95% CI 2.82 to 18.45; p<0.001). In addition, after stratification by promoter methylation in 3 combined genes in the matched normal tissues, we observed a joint effect after adjusting for sex, age at surgery, and adjuvant chemotherapy, yielding a significant OR of 20.35 (95% CI 4.16 to 99.57; p<0.001). DNA methylation status would significantly increase the recurrence risk of CRC with a significant impact on joint effect between DNA methylation and clinical stage, particularly in matched normal tissues. This was attributed to molecular changes that could not be examined on the basis of clinical pathology. Our interaction results may serve as a reference marker for evaluating the risk of recurrence in future studies. ©en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherBMJ PUBLISHING GROUPen_US
dc.relation.ispartofpagefrom1200en_US
dc.relation.ispartofpageto1207en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalJournal of Investigative Medicineen_US
dc.relation.ispartofvolume64en_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsMedicine, General & Internalen_US
dc.subject.keywordsMedicine, Research & Experimentalen_US
dc.subject.keywordsGeneral & Internal Medicineen_US
dc.titleClinical stage and risk of recurrence and mortality: interaction of DNA methylation factors in patients with colorectal canceren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationChang, H-F; Wu, C-C; Sun, C-A; Chu, C-M; Lin, F-G; Hsieh, J-F; Hsu, C-H; Huang, C-H; Yang, T; Tsai, Y-M; Kuan, J-C; Chou, Y-C, Clinical stage and risk of recurrence and mortality: interaction of DNA methylation factors in patients with colorectal cancer, Journal of Investigative Medicine, 2016, 64 (7), pp. 1200-1207en_US
dcterms.dateAccepted2016-05-22
dc.date.updated2021-07-19T23:43:14Z
gro.hasfulltextNo Full Text
gro.griffith.authorChu, Cordia M.


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