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dc.contributor.authorKaram, O
dc.contributor.authorDemaret, P
dc.contributor.authorDuhamel, A
dc.contributor.authorShefler, A
dc.contributor.authorSpinella, PC
dc.contributor.authorStanworth, SJ
dc.contributor.authorTucci, M
dc.contributor.authorLeteurtre, S
dc.contributor.authorButt, W
dc.contributor.authorDelzoppo, C
dc.contributor.authorBain, K
dc.contributor.authorErickson, S
dc.contributor.authorSmalley, N
dc.contributor.authorLong, D
dc.contributor.authoret al.
dc.date.accessioned2022-05-17T04:33:39Z
dc.date.available2022-05-17T04:33:39Z
dc.date.issued2016
dc.identifier.issn2110-5820
dc.identifier.doi10.1186/s13613-016-0197-6
dc.identifier.urihttp://hdl.handle.net/10072/406197
dc.description.abstractBackground: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofpagefrom98
dc.relation.ispartofissue1
dc.relation.ispartofjournalAnnals of Intensive Care
dc.relation.ispartofvolume6
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.titlePerformance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKaram, O; Demaret, P; Duhamel, A; Shefler, A; Spinella, PC; Stanworth, SJ; Tucci, M; Leteurtre, S; for the PlasmaTV investigators, ; Butt, W; Delzoppo, C; Bain, K; Erickson, S; Smalley, N; Long, D; et al., Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions, Annals of Intensive Care, 2016, 6 (1), pp.98
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/)
dc.date.updated2021-07-21T05:57:36Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
gro.hasfulltextFull Text
gro.griffith.authorLong, Debbie A.


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