Show simple item record

dc.contributor.authorOpoku-Damoah, Yaw
dc.contributor.authorZhang, Run
dc.contributor.authorTa, Hang Thu
dc.contributor.authorXu, Zhi Ping
dc.date.accessioned2021-07-23T01:42:52Z
dc.date.available2021-07-23T01:42:52Z
dc.date.issued2021
dc.identifier.issn2047-4830
dc.identifier.doi10.1039/d1bm00941a
dc.identifier.urihttp://hdl.handle.net/10072/406230
dc.description.abstractThe quest to maximize therapeutic efficiency in cancer treatment requires innovative delivery nanoplatforms capable of employing different modules simultaneously. Combination therapy has proven to be one of the best anticancer strategies so far. Herein, we developed a lipid-encapsulated nanoplatform that combines chemotherapy with photoresponsive gas therapy for colon cancer treatment. Carbon monoxide releasing molecule (CORM) and α-tocopheryl succinate (α-TOS) were co-loaded into the lipid layer with core-shell upconversion nanoparticles (UCNPs), which converted 808 nm lights to 360 nm photons for CO release at the tumor site. This nanomedicine (Lipid/UCNP/CORM/α-TOS/FA: LUCTF) possessed enhanced targeting ability, and light-triggered CO release ability for synergistic apoptosis of HCT116 cells via enhanced ROS generation and mitochondria membrane breaking. In vivo data confirmed the significantly enhanced therapeutic efficacy of LUCTF without any significant biosafety issues after intravenous administration. Thus, nanomedicine LUCTF represents a novel way for efficient cancer therapy via combining locally released CO and a compatible chemotherapeutic agent (α-TOS).
dc.description.peerreviewedYes
dc.languageen
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofjournalBiomaterials Science
dc.subject.fieldofresearchAnalytical biochemistry
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode310101
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.titleVitamin E-facilitated Carbon Monoxide Pro-drug Nanomedicine for Efficient Light-Responsive Combination Cancer Therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationOpoku-Damoah, Y; Zhang, R; Ta, HT; Xu, ZP, Vitamin E-facilitated Carbon Monoxide Pro-drug Nanomedicine for Efficient Light-Responsive Combination Cancer Therapy, Biomaterials Science
dc.date.updated2021-07-23T01:07:35Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2021 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorTa, Hang


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record