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dc.contributor.authorHuang, Y
dc.contributor.authorAlzahrani, NA
dc.contributor.authorChua, TC
dc.contributor.authorHuo, YR
dc.contributor.authorMorris, DL
dc.date.accessioned2021-07-25T03:59:38Z
dc.date.available2021-07-25T03:59:38Z
dc.date.issued2016
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/10072/406273
dc.description.abstractAim: The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI). Patients and Methods: This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed. Results: Three hundred and five patients were included in the study. The median overall survival (OS) was 89.3 months (95% confidence interval=58.9-107.6 months). OS at 1, 3 and 5 years of our study cohort was 89.4%, 70.4% and 57.5%, respectively. In terms of the learning curve, the mean duration of operation and hospital mortality decreased (p<0.001 and p=0.006 respectively). A trend for decreasing intensive care unit stay (p=0.497), high dependency unit stay (p=0.042) and total hospital stay (p=0.202) were also recorded. Conclusion: A high PCI alone should not be a contraindication for cytoreductive surgery and PIC in specialized centres.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherInternational Institute of Anticancer Research
dc.publisher.urihttps://ar.iiarjournals.org/content/36/3/1033.long
dc.relation.ispartofpagefrom1033
dc.relation.ispartofpageto1040
dc.relation.ispartofissue3
dc.relation.ispartofjournalAnticancer Research
dc.relation.ispartofvolume36
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.subject.keywordsPeritoneal cancer index
dc.subject.keywordscytoreductive surgery
dc.subject.keywordsperioperative intraperitoneal chemotherapy
dc.titleClinical outcomes of patients with extensive peritoneal carcinomatosis following cytoreductive surgery and perioperative intraperitoneal chemotherapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHuang, Y; Alzahrani, NA; Chua, TC; Huo, YR; Morris, DL, Clinical outcomes of patients with extensive peritoneal carcinomatosis following cytoreductive surgery and perioperative intraperitoneal chemotherapy, Anticancer Research, 2016, 36 (3), pp. 1033-1040
dc.date.updated2021-07-25T03:55:19Z
gro.hasfulltextNo Full Text
gro.griffith.authorChua, Terence


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