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dc.contributor.authorYan, S
dc.contributor.authorZhang, J
dc.contributor.authorYuan, D
dc.contributor.authorZhao, Q
dc.contributor.authorMa, J
dc.contributor.authorLi, WH
dc.date.accessioned2021-07-25T06:29:45Z
dc.date.available2021-07-25T06:29:45Z
dc.date.issued2016
dc.identifier.issn0003-6951
dc.identifier.doi10.1063/1.4968835
dc.identifier.urihttp://hdl.handle.net/10072/406297
dc.description.abstractThe separation of target objects conjugated with magnetic particles is a significant application in biomedicine and clinical diagnosis. Conventional magnetophoresis-based devices use a sheath flow to pre-focus the particles into a single stream and typically operate at a low flow rate. We demonstrate in this work a high-throughput, sheathless, magnetophoretic separation of magnetic and non-magnetic beads in a groove-based channel, and also report on an interesting phenomenon where the same magnetic beads in the same microchannel, but with different setups, has a different particle tracing; a binary mixture of magnetic and non-magnetic beads in a diluted ferrofluid, is then fed into the channel. These magnetic beads are focused near the centreline of the channel by exploiting positive magnetophoresis and microvortices generated by grooves, whereas the non-magnetic beads are focused along the sidewalls of the channel by negative magnetophoresis and hydrophoresis. These magnetic and non-magnetic beads are separated in a wide range of flow rates (up to 80 μl min-1).
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAIP Publishing
dc.relation.ispartofpagefrom214101
dc.relation.ispartofissue21
dc.relation.ispartofjournalApplied Physics Letters
dc.relation.ispartofvolume109
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode51
dc.subject.fieldofresearchcode40
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysics, Applied
dc.subject.keywordsPhysics
dc.subject.keywordsMICROFLUIDIC DEVICE
dc.titleHigh-throughput, sheathless, magnetophoretic separation of magnetic and non-magnetic particles with a groove-based channel
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYan, S; Zhang, J; Yuan, D; Zhao, Q; Ma, J; Li, WH, High-throughput, sheathless, magnetophoretic separation of magnetic and non-magnetic particles with a groove-based channel, Applied Physics Letters, 2016, 109 (21), pp. 214101
dc.date.updated2021-07-25T06:20:37Z
gro.rights.copyright© 2016 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Applied Physics Letters, 109, 214101 (2016) and may be found at https://doi.org/10.1063/1.4968835
gro.hasfulltextFull Text
gro.griffith.authorZhang, Jun


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