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dc.contributor.authorTrembizki, Ella
dc.contributor.authorBuckley, Cameron
dc.contributor.authorBletchly, Cheryl
dc.contributor.authorNimmo, Graeme R
dc.contributor.authorWhiley, David M
dc.date.accessioned2021-07-27T00:41:11Z
dc.date.available2021-07-27T00:41:11Z
dc.date.issued2017
dc.identifier.issn0022-2615
dc.identifier.doi10.1099/jmm.0.000584
dc.identifier.urihttp://hdl.handle.net/10072/406349
dc.description.abstractThe macrolide azithromycin is recommended for treatment of Mycoplasma genitalium infection; however, M. genitalium strains possessing macrolide resistance-mediating mutations (MRMMs) are increasingly being reported. Here, we used the SpeeDx ResistancePlus MG kit, which provides simultaneous detection of M. genitalium and MRMMs, to assess MRMM carriage among M. genitalium infections in Queensland, Australia. Performance characteristics of the ResistancePlus MG kit for M. genitalium detection were compared to in-house PCR. Available M. genitalium PCR-positive (n=67) and negative (n=281) samples from the years 2011 to 2017 were tested using the SpeeDx ResistancePlus MG kit. In total, 63.6 % M. genitalium-positive samples were indicated to harbour MRMMs. The ResistancePlus MG method provided sensitivity and specificity of 97 and 99.6 % respectively compared to in-house PCR for M. genitalium detection. Such high levels of macrolide-resistant M. genitalium raise further concerns over future use of azithromycin for treatment of M. genitalium infection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMICROBIOLOGY SOC
dc.relation.ispartofpagefrom1451
dc.relation.ispartofpageto1453
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Medical Microbiology
dc.relation.ispartofvolume66
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMicrobiology
dc.subject.keywordsUrethritis
dc.subject.keywordsInfection
dc.titleHigh levels of macrolide-resistant Mycoplasma genitalium in Queensland, Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTrembizki, E; Buckley, C; Bletchly, C; Nimmo, GR; Whiley, DM, High levels of macrolide-resistant Mycoplasma genitalium in Queensland, Australia, Journal of Medical Microbiology, 2017, 66 (10), pp. 1451-1453
dc.date.updated2021-07-27T00:38:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorBletchly, Cheryl
gro.griffith.authorNimmo, Graeme R.


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