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dc.contributor.authorDe Martino, Enrico
dc.contributor.authorHides, Julie
dc.contributor.authorElliott, James M
dc.contributor.authorHoggarth, Mark
dc.contributor.authorZange, Jochen
dc.contributor.authorLindsay, Kirsty
dc.contributor.authorDebuse, Dorothée
dc.contributor.authorWinnard, Andrew
dc.contributor.authorBeard, David
dc.contributor.authorCook, Jonathan A
dc.contributor.authorSalomoni, Sauro E
dc.contributor.authorWeber, Tobias
dc.contributor.authorScott, Jonathan
dc.contributor.authorHodges, Paul W
dc.contributor.authorCaplan, Nick
dc.date.accessioned2021-07-27T04:57:58Z
dc.date.available2021-07-27T04:57:58Z
dc.date.issued2021
dc.identifier.issn8750-7587
dc.identifier.doi10.1152/japplphysiol.00990.2020
dc.identifier.urihttp://hdl.handle.net/10072/406375
dc.description.abstractExposure to axial unloading induces adaptations in paraspinal muscles, as shown after spaceflights. This study investigated whether daily exposure to artificial gravity (AG) mitigated lumbar spine flattening and muscle atrophy associated with 60-day head-down tilt (HDT) bed rest (Earth-based space analog). Twenty-four healthy individuals participated in the study: 8 received 30-min continuous AG; 8 received 6 × 5-min AG interspersed with rest periods; and 8 received no AG exposure (control group). Magnetic resonance imaging (MRI) of the lumbopelvic region was conducted at baseline (BDC) and at day 59 of HDT (HDT59). Longitudinal relaxation time (T1)-weighted images were used to assess morphology of the lumbar spine (spinal length, intervertebral disk angles, disk area) and volumes of the lumbar multifidus (LM), lumbar erector spinae (LES), quadratus lumborum (QL), and psoas major (PM) muscles from L1/L2 to L5/S1 vertebral levels. A chemical shift-based two‐point lipid/water Dixon sequence was used to evaluate muscle composition. Results showed that spinal length and disk area increased (P < 0.05); intervertebral disk angles (P < 0.05) and muscle volumes of LM, LES, and QL reduced (P < 0.01); and lipid-to-water ratio for the LM and LES muscles increased (P < 0.01) after HDT59 in all groups. Neither of the AG protocols mitigated the lumbar spinae deconditioning induced by HDT bed rest. The increase in lipid-to-water ratio in LM and LES muscles indicates an increased relative intramuscular lipid concentration. Altered muscle composition in atrophied muscles may impair lumbar spine function after body unloading, which could increase injury risk to vulnerable soft tissues. This relationship needs further investigation.
dc.description.peerreviewedYes
dc.languageen
dc.publisherAmerican Physiological Society
dc.relation.ispartofpagefrom356
dc.relation.ispartofpageto368
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Applied Physiology
dc.relation.ispartofvolume131
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode42
dc.titleLumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day head-down tilt bed rest
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDe Martino, E; Hides, J; Elliott, JM; Hoggarth, M; Zange, J; Lindsay, K; Debuse, D; Winnard, A; Beard, D; Cook, JA; Salomoni, SE; Weber, T; Scott, J; Hodges, PW; Caplan, N, Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day head-down tilt bed rest, Journal of Applied Physiology, 2021, 131 (1), pp. 356-368
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-07-27T01:08:11Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHides, Julie A.


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