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  • Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice

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    Author(s)
    Dilruba, Sayada
    Hasibuzzaman, MM
    Rahman, Mashiur
    Mohanto, Nayan Chandra
    Aktar, Sharmin
    Rahman, Atiqur
    Hossain, Md Imam
    Noman, Abu Shadat Mohammod
    Nikkon, Farjana
    Saud, Zahangir Alam
    Hossain, Khaled
    Griffith University Author(s)
    Aktar, Sharmin
    Year published
    2017
    Metadata
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    Abstract
    Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite (Sa)-induced adverse effects through mice experiments. Methods:Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly (P ...
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    Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite (Sa)-induced adverse effects through mice experiments. Methods:Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly (P < 0.05) higher in Sa-treated mice than those in the control group. RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly (P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly (P < 0.05). Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.
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    Journal Title
    Asian Pacific Journal of Tropical Biomedicine
    Volume
    7
    Issue
    10
    DOI
    https://doi.org/10.1016/j.apjtb.2017.09.001
    Copyright Statement
    © 2017 Hainan Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
    Subject
    Biomedical and clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Tropical Medicine
    Publication URI
    http://hdl.handle.net/10072/406400
    Collection
    • Journal articles

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