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dc.contributor.authorMathai, VK
dc.contributor.authorAung, SY
dc.contributor.authorWong, V
dc.contributor.authorDunn, C
dc.contributor.authorShapiro, J
dc.contributor.authorJalali, A
dc.contributor.authorWong, R
dc.contributor.authorLee, M
dc.contributor.authorTie, J
dc.contributor.authorAnanda, S
dc.contributor.authorKosmider, S
dc.contributor.authorLim, SH
dc.contributor.authorCaird, S
dc.contributor.authorBurge, M
dc.contributor.authoret al.
dc.date.accessioned2021-08-04T00:31:19Z
dc.date.available2021-08-04T00:31:19Z
dc.date.issued2021
dc.identifier.issn1533-0028
dc.identifier.doi10.1016/j.clcc.2021.06.003
dc.identifier.urihttp://hdl.handle.net/10072/406550
dc.description.abstractIntroduction: The optimal management of isolated distant lymph node metastases (IDLNM) from a colorectal primary, is not clearly established. We aimed to analyze the outcomes of patients with IDLNM treated with systemic therapies plus locoregional therapy with curative intent versus systemic therapies with palliative intent. Materials & Methods: Clinical data were collected and reviewed from the Treatment of Recurrent and Advanced Colorectal Cancer registry, a prospective, comprehensive registry for metastatic colorectal cancer (mCRC) treated at multiple tertiary hospitals across Australia. Clinicopathological characteristics, treatment modalities and survival outcomes were analyzed in patients with IDLNM and compared to patients with disease at other sites. Results: Of 3408 mCRC patients diagnosed 2009 to 2020, with median follow-up of 38.0 months, 93 (2.7%) were found to have IDLNM. Compared to mCRC at other sites, patients with IDLNM were younger (mean age: 62.1 vs. 65.6 years, P = .02), more likely to have metachronous disease (57.0% vs. 38.9%, P < .01), be KRAS wild-type (74.6% vs. 53.9%, P< .01) and BRAF mutant (12.9% vs. 6.2%, P = .01). Amongst mCRC patients with IDLNM, 24 (25.8%) received treatment with curative intent and had a significantly better overall median survival than those treated with palliative intent (73.5 months vs. 23.2 months, P = .01). These 24 patients had an overall median survival similar (62.7 months, P = .82) to patients with isolated liver or lung metastases also treated with curative intent. Conclusion: Curative treatment strategies (radiotherapy or surgery), with or without systemic therapy, should be considered for mCRC patients with IDLNM where appropriate as assessed by the multidisciplinary team.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofjournalClinical Colorectal Cancer
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.subject.keywordsColorectal cancer
dc.subject.keywordsCurative
dc.subject.keywordsLymph node
dc.subject.keywordsMetastases
dc.subject.keywordsTreatment
dc.titleTreatment and Outcomes of Oligometastatic Colorectal Cancer Limited to Lymph Node Metastases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMathai, VK; Aung, SY; Wong, V; Dunn, C; Shapiro, J; Jalali, A; Wong, R; Lee, M; Tie, J; Ananda, S; Kosmider, S; Lim, SH; Caird, S; Burge, M; et al., Treatment and Outcomes of Oligometastatic Colorectal Cancer Limited to Lymph Node Metastases, Clinical Colorectal Cancer, 2021
dcterms.dateAccepted2021-06-20
dc.date.updated2021-08-04T00:16:49Z
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.hasfulltextNo Full Text
gro.griffith.authorCaird, Susan


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