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dc.contributor.authorMigdady, I
dc.contributor.authorAmin, M
dc.contributor.authorShoskes, A
dc.contributor.authorHassett, C
dc.contributor.authorCho, SM
dc.contributor.authorGeorge, P
dc.contributor.authorRae-Grant, A
dc.date.accessioned2021-08-04T04:00:14Z
dc.date.available2021-08-04T04:00:14Z
dc.date.issued2021
dc.identifier.issn2052-0492
dc.identifier.doi10.1186/s40560-020-00522-8
dc.identifier.urihttp://hdl.handle.net/10072/406570
dc.description.abstractBackground: Persistent apnea despite an adequate rise in arterial pressure of CO2 is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH changes during the apnea test (AT). We aimed to study the effect of incorporating an arterial pH target < 7.30 during the AT (in addition to the existing PaCO2 threshold) on brain death declarations. Methods: We performed retrospective analysis of consecutive adult patients who were diagnosed with BD and underwent AT at the Cleveland Clinic over the last 10 years. Data regarding baseline and post-AT blood gas analyses were collected and analyzed. Results: Ninety-eight patients underwent AT in the study period, which was positive in 89 (91%) and inconclusive in 9 (9%) patients. The mean age was 50 years old (standard deviation [SD] 16) and 54 (55%) were female. The most common etiology BD was hypoxic ischemic brain injury (HIBI) due to cardiac arrest (42%). Compared to those with positive AT, patients with inconclusive AT had a higher post-AT pH (7.24 vs 7.17, p = 0.01), lower PaO2 (47 vs 145, p < 0.01), and a lower PaCO2 (55 vs 73, p = 0.01). Among patients with a positive AT using PaCO2 threshold alone, the frequency of patients with post-AT pH < 7.30 was 95% (83/87). Conclusion: Implementing a BD criteria requiring both arterial pH and PaCO2 thresholds reduced the total number of positive ATs; these inconclusive cases would have required longer duration of AT to reach both targets, repeated ATs, or ancillary studies to confirm BD. The impact of this on the overall number BD declarations requires further research.
dc.description.peerreviewedYes
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom13
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Intensive Care
dc.relation.ispartofvolume9
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleThe effect of incorporating an arterial pH target during apnea test for brain death determination
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMigdady, I; Amin, M; Shoskes, A; Hassett, C; Cho, SM; George, P; Rae-Grant, A, The effect of incorporating an arterial pH target during apnea test for brain death determination, Journal of Intensive Care, 2021, 9 (1), pp. 13
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-08-04T03:38:56Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorAmin, Moein


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