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  • Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

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    Author(s)
    Jamshidy, Ladan
    Tadakamadla, Santosh Kumar
    Choubsaz, Parsia
    Sadeghi, Masoud
    Tadakamadla, Jyothi
    Griffith University Author(s)
    Tadakamadla, Jyothi
    Tadakamdla, Santosh Kumar K.
    Year published
    2021
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    Abstract
    Genetic susceptibility has been reported to be an important risk factor for peri-implant disease (PID). The aim of this meta-analysis was to assess the association between TNF-α and IL-10 polymorphisms and PID susceptibility. The Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases were searched for studies published until 12 April 2021. RevMan 5.3, CMA 2.0, SPSS 22.0, and trial sequential analysis software were used. Twelve studies were included in our analysis. The pooled ORs for the association of TNF-α (-308 G > A), IL-10 (-1082 A > G), IL-10 (-819 C > T), and IL-10 (-592 A > C) polymorphisms were 1.12, ...
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    Genetic susceptibility has been reported to be an important risk factor for peri-implant disease (PID). The aim of this meta-analysis was to assess the association between TNF-α and IL-10 polymorphisms and PID susceptibility. The Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases were searched for studies published until 12 April 2021. RevMan 5.3, CMA 2.0, SPSS 22.0, and trial sequential analysis software were used. Twelve studies were included in our analysis. The pooled ORs for the association of TNF-α (-308 G > A), IL-10 (-1082 A > G), IL-10 (-819 C > T), and IL-10 (-592 A > C) polymorphisms were 1.12, 0.93, 1.35, and 0.77 for allelic; 1.42, 0.95, 3.41, and 0.34 for homozygous; 1.19, 1.88, 1.23, and 0.49 for heterozygous, 1.53, 1.12, 1.41, and 0.39 for recessive; and 1.16, 1.87, 2.65, and 0.75 for dominant models, respectively, with all the estimates being insignificant. The results showed an association between TNF-α (-308 G > A) polymorphism and the risk of PID in patients of Asian ethnicity (OR = 1.59; p = 0.03). The present meta-analysis illustrated that TNF-α (-308 G > A), IL-10 (-1082 A > G), IL-10 (-819 C > T), and IL-10 (-592 A > C) polymorphisms were not associated with the risk of PID, whereas TNF-α (-308 G > A) polymorphism was associated with an elevated risk of PID in Asian patients.
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    Journal Title
    International Journal of Environmental Research and Public Health
    Volume
    18
    Issue
    14
    DOI
    https://doi.org/10.3390/ijerph18147697
    Copyright Statement
    © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Dentistry
    bone loss
    cytokine
    implant failure
    peri-implant disease
    peri-implantitis
    Publication URI
    http://hdl.handle.net/10072/406579
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    • Journal articles

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