dc.contributor.author | Glasbey, JC | |
dc.contributor.author | Nepogodiev, D | |
dc.contributor.author | Simoes, JFF | |
dc.contributor.author | Omar, OM | |
dc.contributor.author | Venn, ML | |
dc.contributor.author | Evans, JP | |
dc.contributor.author | Futaba, K | |
dc.contributor.author | Knowles, CH | |
dc.contributor.author | Minaya-Bravo, A | |
dc.contributor.author | Mohan, H | |
dc.contributor.author | Chand, M | |
dc.contributor.author | Pockney, P | |
dc.contributor.author | Wullschleger, Martin | |
dc.contributor.author | Gundara, Justin | |
dc.contributor.author | et al. | |
dc.date.accessioned | 2021-08-04T04:54:21Z | |
dc.date.available | 2021-08-04T04:54:21Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1462-8910 | |
dc.identifier.doi | 10.1111/codi.15431 | |
dc.identifier.uri | http://hdl.handle.net/10072/406584 | |
dc.description.abstract | Aim: This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. Method: This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data. Results: From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58–14.06), postoperative SARS-CoV-2 (16.90, 7.86–36.38), male sex (2.46, 1.01–5.93), age >70 years (2.87, 1.32–6.20) and advanced cancer stage (3.43, 1.16–10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%). Conclusion: Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks. | |
dc.description.peerreviewed | Yes | |
dc.language | en | |
dc.publisher | Wiley | |
dc.relation.ispartofpagefrom | 732 | |
dc.relation.ispartofpageto | 749 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Colorectal Disease | |
dc.relation.ispartofvolume | 23 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.title | Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Glasbey, JC; Nepogodiev, D; Simoes, JFF; Omar, OM; Venn, ML; Evans, JP; Futaba, K; Knowles, CH; Minaya-Bravo, A; Mohan, H; Chand, M; Pockney, P; Wullschleger, M; Gundara, J; et al., Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic, Colorectal Disease, 2021, 23 (3), pp. 732-749 | |
dc.date.updated | 2021-08-04T04:50:54Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Wullschleger, Martin | |
gro.griffith.author | Gundara, Justin | |