Show simple item record

dc.contributor.authorGlasbey, JC
dc.contributor.authorNepogodiev, D
dc.contributor.authorSimoes, JFF
dc.contributor.authorOmar, OM
dc.contributor.authorVenn, ML
dc.contributor.authorEvans, JP
dc.contributor.authorFutaba, K
dc.contributor.authorKnowles, CH
dc.contributor.authorMinaya-Bravo, A
dc.contributor.authorMohan, H
dc.contributor.authorChand, M
dc.contributor.authorPockney, P
dc.contributor.authorWullschleger, Martin
dc.contributor.authorGundara, Justin
dc.contributor.authoret al.
dc.date.accessioned2021-08-04T04:54:21Z
dc.date.available2021-08-04T04:54:21Z
dc.date.issued2021
dc.identifier.issn1462-8910
dc.identifier.doi10.1111/codi.15431
dc.identifier.urihttp://hdl.handle.net/10072/406584
dc.description.abstractAim: This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. Method: This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data. Results: From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58–14.06), postoperative SARS-CoV-2 (16.90, 7.86–36.38), male sex (2.46, 1.01–5.93), age >70 years (2.87, 1.32–6.20) and advanced cancer stage (3.43, 1.16–10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%). Conclusion: Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks.
dc.description.peerreviewedYes
dc.languageen
dc.publisherWiley
dc.relation.ispartofpagefrom732
dc.relation.ispartofpageto749
dc.relation.ispartofissue3
dc.relation.ispartofjournalColorectal Disease
dc.relation.ispartofvolume23
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleOutcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGlasbey, JC; Nepogodiev, D; Simoes, JFF; Omar, OM; Venn, ML; Evans, JP; Futaba, K; Knowles, CH; Minaya-Bravo, A; Mohan, H; Chand, M; Pockney, P; Wullschleger, M; Gundara, J; et al., Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic, Colorectal Disease, 2021, 23 (3), pp. 732-749
dc.date.updated2021-08-04T04:50:54Z
gro.hasfulltextNo Full Text
gro.griffith.authorWullschleger, Martin
gro.griffith.authorGundara, Justin


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record