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dc.contributor.authorPaluncic, Jasmina
dc.contributor.authorKovacevic, Zaklina
dc.contributor.authorJansson, Patric J
dc.contributor.authorKalinowski, Danuta
dc.contributor.authorMerlot, Angelika M
dc.contributor.authorHuang, Michael L-H
dc.contributor.authorLok, Hiu Chuen
dc.contributor.authorSahni, Sumit
dc.contributor.authorLane, Darius JR
dc.contributor.authorRichardson, Des R
dc.date.accessioned2021-08-15T22:30:06Z
dc.date.available2021-08-15T22:30:06Z
dc.date.issued2016
dc.identifier.issn0167-4889
dc.identifier.doi10.1016/j.bbamcr.2016.01.025
dc.identifier.urihttp://hdl.handle.net/10072/406842
dc.description.abstractMelanoma has markedly increased worldwide during the past several decades in the Caucasian population and is responsible for 80% of skin cancer deaths. Considering that metastatic melanoma is almost completely resistant to most current therapies and is linked with a poor patient prognosis, it is crucial to further investigate potential molecular targets. Major cell-autonomous drivers in the pathogenesis of this disease include the classical MAPK (i.e., RAS-RAF-MEK-ERK), WNT, and PI3K signaling pathways. These pathways play a major role in defining the progression of melanoma, and some have been the subject of recent pharmacological strategies to treat this belligerent disease. This review describes the latest advances in the understanding of melanoma progression and the major molecular pathways involved. In addition, we discuss the roles of emerging molecular players that are involved in melanoma pathogenesis, including the functional role of the melanoma tumor antigen, p97/MFI2 (melanotransferrin).
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom770
dc.relation.ispartofpageto784
dc.relation.ispartofissue4
dc.relation.ispartofjournalBiochimica et Biophysica Acta (BBA) - Molecular Cell Research
dc.relation.ispartofvolume1863
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsMelanoma
dc.titleRoads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPaluncic, J; Kovacevic, Z; Jansson, PJ; Kalinowski, D; Merlot, AM; Huang, ML-H; Lok, HC; Sahni, S; Lane, DJR; Richardson, DR, Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016, 1863 (4), pp. 770-784
dcterms.dateAccepted2016-01-29
dc.date.updated2021-08-12T04:13:50Z
gro.hasfulltextNo Full Text
gro.griffith.authorRichardson, Des R.


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