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dc.contributor.authorRozencwajg, Sacha
dc.contributor.authorHeinsar, Silver
dc.contributor.authorSuen, Jacky
dc.contributor.authorBassi, Gianluigi Li
dc.contributor.authorMalfertheiner, Maximilian
dc.contributor.authorVercaemst, Leen
dc.contributor.authorBroman, Lars Mikael
dc.contributor.authorSchmidt, Matthieu
dc.contributor.authorCombes, Alain
dc.contributor.authorRatsep, Indrek
dc.contributor.authorFraser, John F
dc.contributor.authorMillar, Jonathan E
dc.date.accessioned2021-08-15T23:19:39Z
dc.date.available2021-08-15T23:19:39Z
dc.date.issued2020
dc.identifier.issn2197-425X
dc.identifier.doi10.1186/s40635-020-00303-5
dc.identifier.urihttp://hdl.handle.net/10072/406853
dc.description.abstractOBJECTIVES: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used to treat patients with refractory severe heart failure. Large animal models are developed to help understand physiology and build translational research projects. In order to better understand those experimental models, we conducted a systematic literature review of animal models combining heart failure and VA-ECMO. STUDIES SELECTION: A systematic review was performed using Medline via PubMed, EMBASE, and Web of Science, from January 1996 to January 2019. Animal models combining experimental acute heart failure and ECMO were included. Clinical studies, abstracts, and studies not employing VA-ECMO were excluded. DATA EXTRACTION: Following variables were extracted, relating to four key features: (1) study design, (2) animals and their peri-experimental care, (3) heart failure models and characteristics, and (4) ECMO characteristics and management. RESULTS: Nineteen models of heart failure and VA-ECMO were included in this review. All were performed in large animals, the majority (n = 13) in pigs. Acute myocardial infarction (n = 11) with left anterior descending coronary ligation (n = 9) was the commonest mean of inducing heart failure. Most models employed peripheral VA-ECMO (n = 14) with limited reporting. CONCLUSION: Among models that combined severe heart failure and VA-ECMO, there is a large heterogeneity in both design and reporting, as well as methods employed for heart failure. There is a need for standardization of reporting and minimum dataset to ensure translational research achieve high-quality standards.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSpringer
dc.relation.ispartofpagefrom16
dc.relation.ispartofissue1
dc.relation.ispartofjournalIntensive Care Medicine Experimental
dc.relation.ispartofvolume8
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCritical Care Medicine
dc.subject.keywordsGeneral & Internal Medicine
dc.subject.keywordsHeart failure
dc.titleHeart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRozencwajg, S; Heinsar, S; Suen, J; Bassi, GL; Malfertheiner, M; Vercaemst, L; Broman, LM; Schmidt, M; Combes, A; Ratsep, I; Fraser, JF; Millar, JE, Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models, Intensive Care Medicine Experimental, 2020, 8 (1), pp. 16
dcterms.dateAccepted2020-05-11
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-08-11T22:49:24Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.


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