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dc.contributor.authorWeichert, S
dc.contributor.authorKoromyslova, A
dc.contributor.authorSingh, BK
dc.contributor.authorHansman, S
dc.contributor.authorJennewein, S
dc.contributor.authorSchroten, H
dc.contributor.authorHansman, GS
dc.date.accessioned2021-08-18T04:22:57Z
dc.date.available2021-08-18T04:22:57Z
dc.date.issued2016
dc.identifier.issn1098-5514
dc.identifier.doi10.1128/JVI.03223-15
dc.identifier.urihttp://hdl.handle.net/10072/407048
dc.description.abstractHisto-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL and 3FL structurally mimic HBGAs. These results suggest that 2'FL and 3FL might act as naturally occurring decoys in humans.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofpagefrom4843
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Virology
dc.relation.ispartofvolume90
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchVirology
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310706
dc.subject.fieldofresearchcode42
dc.subject.fieldofresearchcode30
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBLOOD-GROUP ANTIGENS
dc.subject.keywordsBINDING SPECIFICITY
dc.titleStructural Basis for Norovirus Inhibition by Human Milk Oligosaccharides
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWeichert, S; Koromyslova, A; Singh, BK; Hansman, S; Jennewein, S; Schroten, H; Hansman, GS, Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides, Journal of Virology, 2016, 90 (9), pp. 4843-4848
dcterms.dateAccepted2016-02-08
dc.date.updated2021-08-17T22:51:37Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorHansman, Grant S.


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