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  • Substitution of ROTEM FIBTEM A5 for A10 in trauma: an observational study building a case for more rapid analysis of coagulopathy

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    Accepted Manuscript (AM)
    Author(s)
    Blayney, A
    McCullough, J
    Wake, E
    Walters, K
    Campbell, D
    Ho, D
    Chan, E
    Chalasani, A
    Winearls, J
    Griffith University Author(s)
    Campbell, Donald G.
    Ho, Debbie T.
    Chan, Erick C.
    Wake, Liz
    Year published
    2021
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    Abstract
    Purpose: Rotational thromboelastometry (ROTEM®) allows guided blood product resuscitation to correct trauma-induced coagulopathy in bleeding trauma patients. FIBTEM amplitude at 10 min (A10) has been widely used to identify hypofibrinogenaemia; locally a threshold of < 11 mm has guided fibrinogen replacement. Amplitude at 5 min (A5) carries an inherent time advantage. The primary aim was to explore the relationship between FIBTEM A5 and A10 in a trauma. Secondary aim was to investigate the use of A5 as a surrogate for A10 within a fibrinogen-replacement algorithm. Methods: Retrospective observational cohort study of arrival ...
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    Purpose: Rotational thromboelastometry (ROTEM®) allows guided blood product resuscitation to correct trauma-induced coagulopathy in bleeding trauma patients. FIBTEM amplitude at 10 min (A10) has been widely used to identify hypofibrinogenaemia; locally a threshold of < 11 mm has guided fibrinogen replacement. Amplitude at 5 min (A5) carries an inherent time advantage. The primary aim was to explore the relationship between FIBTEM A5 and A10 in a trauma. Secondary aim was to investigate the use of A5 as a surrogate for A10 within a fibrinogen-replacement algorithm. Methods: Retrospective observational cohort study of arrival ROTEM results from 1539 consecutive trauma patients at a Level 1 trauma centre in Australia. Consistency of agreement between FIBTEM A5 and A10 was assessed. A new fibrinogen replacement threshold was developed for A5 using the A5–A10 bias; this was clinically compared to the existing A10 threshold. Results: FIBTEM A5 displayed excellent consistency of agreement with A10. Intraclass correlation coefficient = 0.972 (95% confidence interval [CI] 0.969–0.974). Bias of A5 to A10 was − 1.49 (95% CI 1.43–1.56) mm. 19.34% patients met the original local threshold of A10 < 11 mm; 19.28% patients met the new, bias-adjusted threshold of A5 < 10 mm. Conclusion: ROTEM FIBTEM A5 reliably predicts A10 in trauma. This further validates use of the A5 result over A10 allowing faster decision-making in time-critical resuscitation of trauma patients. A modification of -1 to the A10 threshold might be appropriate for use with the A5 value in trauma patients.
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    Journal Title
    European Journal of Trauma and Emergency Surgery
    DOI
    https://doi.org/10.1007/s00068-021-01652-w
    Copyright Statement
    © Springer-Verlag GmbH Germany, part of Springer Nature 2021. This is an electronic version of an article published in European Journal of Trauma and Emergency Surgery, 2021. European Journal of Trauma and Emergency Surgery is available online at: http://link.springer.com/ with the open URL of your article.
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/407063
    Collection
    • Journal articles

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