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  • In vitro studies evaluating the efficacy of mouth rinses on Sars-Cov-2: A systematic review

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    Tadakamadla508432-Published.pdf (650.8Kb)
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    Version of Record (VoR)
    Author(s)
    Tadakamadla, Jyothi
    Boccalari, Elisa
    Rathore, Vatsna
    Dolci, Carolina
    Tartaglia, Gianluca M
    Tadakamadla, Santosh Kumar
    Griffith University Author(s)
    Rathore, Vatsna
    Tadakamadla, Jyothi
    Tadakamdla, Santosh Kumar K.
    Year published
    2021
    Metadata
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    Abstract
    This systematic review aims to evaluate the evidence on the efficacy of mouth rinses on SARS-CoV-2 from in vitro studies. Five electronic databases were searched up to February 2021; no language or time restrictions were used. Two independent reviewers conducted both selection and data extraction processes. The toxicological data reliability assessment tool was used to evaluate the risk of bias. Starting from 239 articles, retrieved by the electronic search, only eight studies were included in our systematic review. Povidone Iodine (PVP-I) was effective in killing SARS-CoV-2, demonstrated higher virucidal activity than other ...
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    This systematic review aims to evaluate the evidence on the efficacy of mouth rinses on SARS-CoV-2 from in vitro studies. Five electronic databases were searched up to February 2021; no language or time restrictions were used. Two independent reviewers conducted both selection and data extraction processes. The toxicological data reliability assessment tool was used to evaluate the risk of bias. Starting from 239 articles, retrieved by the electronic search, only eight studies were included in our systematic review. Povidone Iodine (PVP-I) was effective in killing SARS-CoV-2, demonstrated higher virucidal activity than other commonly used active ingredients. Conflicting results were found about the effectiveness of Chlorhexidine (CHX) while hydrogen peroxide (H2O2) proved less effective than PVP-I. Other active ingredients, such as quaternary ammonium compounds and Ethanol (particularly when combined with essential oils), have also shown promising results in reducing viral load, with results comparable to PVP-I.
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    Journal Title
    Journal of Infection and Public Health
    Volume
    14
    Issue
    9
    DOI
    https://doi.org/10.1016/j.jiph.2021.07.020
    Copyright Statement
    © 2021 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
    Subject
    Other health sciences
    Public health
    Chlorhexidine
    Hydrogen peroxide
    Mouth rinse
    Povidone-iodine
    SARS-CoV-2
    Publication URI
    http://hdl.handle.net/10072/407143
    Collection
    • Journal articles

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