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dc.contributor.authorYoung, GM
dc.contributor.authorKrastins, D
dc.contributor.authorChang, D
dc.contributor.authorLam, J
dc.contributor.authorQuah, J
dc.contributor.authorStanton, T
dc.contributor.authorRussell, F
dc.contributor.authorGreaves, K
dc.contributor.authorKriel, Y
dc.contributor.authorAskew, CD
dc.date.accessioned2021-08-23T04:25:03Z
dc.date.available2021-08-23T04:25:03Z
dc.date.issued2021
dc.identifier.issn1443-9506
dc.identifier.doi10.1016/j.hlc.2021.07.004
dc.identifier.urihttp://hdl.handle.net/10072/407174
dc.description.abstractBackground and Aim: Contrast-enhanced ultrasound (CEUS) measures of post-occlusion skeletal muscle microvascular responsiveness demonstrate the microvascular dysfunction associated with ageing and age-related disease. However, the accessibility of CEUS is limited by the need for intravenous administration of ultrasound contrast agents and sophisticated imaging analysis. Alternative methods are required for the broader assessment of microvascular dysfunction in research and clinical settings. Therefore, we aimed to evaluate the level of association and agreement between CEUS and near-infrared spectroscopy (NIRS)-derived measures of post-occlusion skeletal muscle microvascular responsiveness in older adults. Methods: During supine rest, participants (n=15, 67±11 years) underwent 5 minutes of thigh cuff-occlusion (200 mmHg). Post-occlusion CEUS measures of calf muscle microvascular responsiveness were made, including time to 95% peak acoustic intensity (TTP95 AI) and the rate of rise (slope AI). Simultaneous measures, including time to 95% peak oxygenated haemoglobin (TTP95 O2Hb) and slope O2Hb, were made using continuous-wave NIRS in the same muscle region. Results: There were strong correlations between TTP95 measures derived from CEUS and NIRS (r=0.834, p=<0.001) and the corresponding measures of slope (r=0.735, p=0.004). The limits of agreement demonstrated by Bland Altman plot analyses for CEUS and NIRS-derived measures of TTP95 (-9.67–1.98 s) and slope (-1.29–5.23%. s-1) were smaller than the minimum differences expected in people with microvascular dysfunction. Conclusions: The strong correlations and level of agreement in the present study support the use of NIRS as a non-invasive, portable and cost-effective method for assessing post-occlusion skeletal muscle microvascular responsiveness in older adults.
dc.description.peerreviewedYes
dc.languageen
dc.publisherElsevier BV
dc.relation.ispartofjournalHeart Lung and Circulation
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3201
dc.titleThe Association Between Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy-Derived Measures of Calf Muscle Microvascular Responsiveness in Older Adults
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYoung, GM; Krastins, D; Chang, D; Lam, J; Quah, J; Stanton, T; Russell, F; Greaves, K; Kriel, Y; Askew, CD, The Association Between Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy-Derived Measures of Calf Muscle Microvascular Responsiveness in Older Adults, Heart Lung and Circulation, 2021
dc.date.updated2021-08-23T04:23:25Z
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.hasfulltextNo Full Text
gro.griffith.authorGreaves, Kim
gro.griffith.authorStanton, Tony


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