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  • Investigation of viscoelastic focusing of particles and cells in a zigzag microchannel.

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    Yadav507931-Accepted.pdf (1.804Mb)
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    Accepted Manuscript (AM)
    Author(s)
    Yuan, Dan
    Yadav, Sharda
    Ta, Hang
    Fallahi, Hedieh
    An, Hongjie
    Kashaninejad, Navid
    Ooi, Chin Hong
    Nguyen, Nam-Trung
    Zhang, Jun
    Griffith University Author(s)
    Yadav, Sharda
    Ta, Hang
    Kashaninejad, Navid
    An, Hongjie
    Ooi, Chin Hong
    Zhang, Jun
    Nguyen, Nam-Trung
    Year published
    2021
    Metadata
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    Abstract
    Microfluidic particle focusing has been a vital prerequisite step in sample preparation for downstream particle separation, counting, detection or analysis, and has attracted broad applications in biomedical and chemical areas. Besides all the active and passive focusing methods in Newtonian fluids, particle focusing in viscoelastic fluids has been attracting increasing interest because of its advantages induced by intrinsic fluid property. However, to achieve a well-defined focusing position, there is a need to extend channel lengths when focusing micrometer-sized or sub-micro-sized particles, which would result in the size ...
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    Microfluidic particle focusing has been a vital prerequisite step in sample preparation for downstream particle separation, counting, detection or analysis, and has attracted broad applications in biomedical and chemical areas. Besides all the active and passive focusing methods in Newtonian fluids, particle focusing in viscoelastic fluids has been attracting increasing interest because of its advantages induced by intrinsic fluid property. However, to achieve a well-defined focusing position, there is a need to extend channel lengths when focusing micrometer-sized or sub-micro-sized particles, which would result in the size increase of the microfluidic devices. This work investigated the sheathless viscoelastic focusing of particles and cells in a zigzag microfluidic channel. Benefit from the zigzag structure of the channel, the channel length and the footprint of the device can be reduced without sacrificing the focusing performance. In this work, the viscoelastic focusing, including the focusing of 10 μm polystyrene particles, 5 μm polystyrene particles, 5 μm magnetic particles, white blood cells (WBCs), red blood cells (RBCs), and cancer cells, were all demonstrated. Moreover, magnetophoretic separation of magnetic and nonmagnetic particles after viscoelastic pre-focusing was shown. This focusing technique has the potential to be used in a range of biomedical applications. This article is protected by copyright. All rights reserved.
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    Journal Title
    Electrophoresis
    DOI
    https://doi.org/10.1002/elps.202100126
    Copyright Statement
    © 2021 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Investigation of viscoelastic focusing of particles and cells in a zigzag microchannel., Electrophoresis, 2021, which has been published in final form at https://doi.org/10.1002/elps.202100126. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Analytical chemistry
    Biochemistry and cell biology
    Chemical engineering
    Magnetophoresis
    Particle focusing
    Particle separation
    Viscoelastic fluid
    Publication URI
    http://hdl.handle.net/10072/407187
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    • Journal articles

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