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dc.contributor.authorYuan, Dan
dc.contributor.authorYadav, Sharda
dc.contributor.authorTa, Hang
dc.contributor.authorFallahi, Hedieh
dc.contributor.authorAn, Hongjie
dc.contributor.authorKashaninejad, Navid
dc.contributor.authorOoi, Chin Hong
dc.contributor.authorNguyen, Nam-Trung
dc.contributor.authorZhang, Jun
dc.date.accessioned2021-08-23T05:27:14Z
dc.date.available2021-08-23T05:27:14Z
dc.date.issued2021
dc.identifier.issn0173-0835
dc.identifier.doi10.1002/elps.202100126
dc.identifier.urihttp://hdl.handle.net/10072/407187
dc.description.abstractMicrofluidic particle focusing has been a vital prerequisite step in sample preparation for downstream particle separation, counting, detection or analysis, and has attracted broad applications in biomedical and chemical areas. Besides all the active and passive focusing methods in Newtonian fluids, particle focusing in viscoelastic fluids has been attracting increasing interest because of its advantages induced by intrinsic fluid property. However, to achieve a well-defined focusing position, there is a need to extend channel lengths when focusing micrometer-sized or sub-micro-sized particles, which would result in the size increase of the microfluidic devices. This work investigated the sheathless viscoelastic focusing of particles and cells in a zigzag microfluidic channel. Benefit from the zigzag structure of the channel, the channel length and the footprint of the device can be reduced without sacrificing the focusing performance. In this work, the viscoelastic focusing, including the focusing of 10 μm polystyrene particles, 5 μm polystyrene particles, 5 μm magnetic particles, white blood cells (WBCs), red blood cells (RBCs), and cancer cells, were all demonstrated. Moreover, magnetophoretic separation of magnetic and nonmagnetic particles after viscoelastic pre-focusing was shown. This focusing technique has the potential to be used in a range of biomedical applications. This article is protected by copyright. All rights reserved.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofjournalElectrophoresis
dc.subject.fieldofresearchMicrofluidics and nanofluidics
dc.subject.fieldofresearchBiomedical instrumentation
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchcode401210
dc.subject.fieldofresearchcode400305
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3401
dc.subject.keywordsMagnetophoresis
dc.subject.keywordsParticle focusing
dc.subject.keywordsParticle separation
dc.subject.keywordsViscoelastic fluid
dc.titleInvestigation of viscoelastic focusing of particles and cells in a zigzag microchannel.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYuan, D; Yadav, S; Ta, H; Fallahi, H; An, H; Kashaninejad, N; Ooi, CH; Nguyen, N-T; Zhang, J, Investigation of viscoelastic focusing of particles and cells in a zigzag microchannel., Electrophoresis, 2021
dcterms.dateAccepted2021-08-05
dc.date.updated2021-08-23T05:00:02Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.rights.copyright© 2021 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Investigation of viscoelastic focusing of particles and cells in a zigzag microchannel., Electrophoresis, 2021, which has been published in final form at https://doi.org/10.1002/elps.202100126. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorYadav, Sharda
gro.griffith.authorTa, Hang
gro.griffith.authorKashaninejad, Navid
gro.griffith.authorAn, Hongjie
gro.griffith.authorOoi, Chin Hong
gro.griffith.authorZhang, Jun
gro.griffith.authorNguyen, Nam-Trung


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