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dc.contributor.authorRoberts, Matthew A
dc.contributor.authorDarssan, Darsy
dc.contributor.authorBadve, Sunil V
dc.contributor.authorCarroll, Robert P
dc.contributor.authorFahim, Magid A
dc.contributor.authorHaluska, Brian A
dc.contributor.authorHawley, Carmel M
dc.contributor.authorIsbel, Nicole M
dc.contributor.authorMarshall, Mark R
dc.contributor.authorPascoe, Elaine M
dc.contributor.authorStanton, Tony
dc.contributor.authorTan, Ken-Soon
dc.contributor.authorTonkin, Andrew M
dc.contributor.authorVergara, Liza A
dc.contributor.authoret al.
dc.date.accessioned2023-06-08T00:43:49Z
dc.date.available2023-06-08T00:43:49Z
dc.date.issued2017
dc.identifier.issn1420-4096en_US
dc.identifier.doi10.1159/000485589en_US
dc.identifier.urihttp://hdl.handle.net/10072/407240
dc.description.abstractBackground/Aims: Cardiac biomarkers are associated with cardiac abnormalities and adverse outcomes in dialysis patients. Our aim was to report the effect of the beta-blocker carvedilol on cardiac biomarkers in adult dialysis patients. Methods: The Beta-Blocker to Lower Cardiovascular Dialysis Events Feasibility Study was a randomized controlled trial comparing carvedilol to placebo. Serum and plasma were collected before the run-in, then 6 and 12 months post-randomization to measure B-type Natriuretic Peptide (BNP), N-terminal BNP (NT-ProBNP), high-sensitivity cardiac troponins I (hs-TnI) and T (hs-TnT), and galectin-3. Left ventricular global longitudinal strain (GLS) was measured by echocardiography at baseline. Results: Seventy-two participants were recruited of whom 49 completed the run-in and were randomized to carvedilol (n=26) or placebo (n=23). Baseline echocardiography demonstrated median (inter-quartile range) GLS of -14.27% (-16.63 to -11.93). NTproBNP and hs-TnT correlated with GLS (Spearman's rho=0.34 [p=0.018] and rho=0.28 [p=0.049], respectively). Median change scores from baseline to 12 months did not differ significantly between participants with complete biomarker data randomized to carvedilol (n=15) or placebo (n=16) for any biomarkers. Conclusions: NT-proBNP and hs-TnT were associated with GLS. However, changes in levels of the biomarkers from baseline to 12 months were not different between groups randomized to carvedilol and placebo.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherKARGERen_US
dc.relation.ispartofpagefrom1033en_US
dc.relation.ispartofpageto1044en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalKidney and Blood Pressure Researchen_US
dc.relation.ispartofvolume42en_US
dc.subject.fieldofresearchClinical sciencesen_US
dc.subject.fieldofresearchcode3202en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsPhysiologyen_US
dc.subject.keywordsUrology & Nephrologyen_US
dc.subject.keywordsPeripheral Vascular Diseaseen_US
dc.titleCarvedilol and Cardiac Biomarkers in Dialysis Patients: Secondary Analysis of a Randomized Controlled Trialen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationRoberts, MA; Darssan, D; Badve, SV; Carroll, RP; Fahim, MA; Haluska, BA; Hawley, CM; Isbel, NM; Marshall, MR; Pascoe, EM; Stanton, T; Tan, K-S; Tonkin, AM; Vergara, LA; et al, Carvedilol and Cardiac Biomarkers in Dialysis Patients: Secondary Analysis of a Randomized Controlled Trial, Kidney and Blood Pressure Research, 2017, 42 (6), pp. 1033-1044en_US
dcterms.dateAccepted2017-09-03
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.date.updated2021-08-24T04:42:11Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2017 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.en_US
gro.hasfulltextFull Text
gro.griffith.authorTan, Ken-Soon
gro.griffith.authorStanton, Tony


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