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dc.contributor.authorZhang, Chang-hua
dc.contributor.authorZhou, Bu-gao
dc.contributor.authorSheng, Jun-qing
dc.contributor.authorChen, Yang
dc.contributor.authorCao, Ying-qian
dc.contributor.authorChen, Chen
dc.date.accessioned2021-08-26T03:59:51Z
dc.date.available2021-08-26T03:59:51Z
dc.date.issued2020
dc.identifier.issn1043-6618
dc.identifier.doi10.1016/j.phrs.2020.104984
dc.identifier.urihttp://hdl.handle.net/10072/407306
dc.description.abstractThe prevalence of nonalcoholic fatty liver disease (NAFLD) in the general population is estimated at 25 %, and there is currently no effective treatment of NAFLD. Although insulin resistance (IR) is not the only factor causing the pathogenesis of NAFLD, hepatic IR has a cause-effective relationship with NAFLD. Improving hepatic IR is a potential therapeutic strategy to treat NAFLD. This review highlights the molecular mechanisms of hepatic IR in the development of NAFLD. Available data on potential drugs including glucagon-like peptide 1 receptor (GLP-1) agonists, peroxisome proliferator-activated receptor (PPAR-γ/α/δ) agonists, farnesoid X receptor (FXR) agonists, etc. are carefully discussed.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom104984
dc.relation.ispartofjournalPharmacological Research
dc.relation.ispartofvolume159
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMolecular mechanism
dc.subject.keywordsHepatic insulin resistance
dc.subject.keywordsPharmacy
dc.titleMolecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhang, C-H; Zhou, B-G; Sheng, J-Q; Chen, Y; Cao, Y-Q; Chen, C, Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies, Pharmacological Research, 2020, 159, pp. 104984
dcterms.dateAccepted2020-05-29
dc.date.updated2021-08-24T23:18:00Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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