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dc.contributor.authorAnstey, Chris
dc.contributor.authorCampbell, Victoria
dc.contributor.authorRichardson, Alexander
dc.date.accessioned2021-09-02T03:25:59Z
dc.date.available2021-09-02T03:25:59Z
dc.date.issued2016
dc.identifier.issn0253-5068
dc.identifier.doi10.1159/000446979
dc.identifier.urihttp://hdl.handle.net/10072/407503
dc.description.abstractBackground/Aims: The study aimed to compare the changes in biochemistry occurring in patients undergoing continuous renal replacement therapy (CRRT) using 2 trisodium citrate solutions, Baxter hemofiltration fluid containing 18 mmol/l (C18) and Baxter NamSol, a custom manufactured solution containing 15 mmol/l (C15), both delivered as regional citrate anticoagulation (RCA) predilution fluids for hemofiltration. Methods: This is a prospective randomized control trial conducted in a major regional adult intensive care unit. Patients were randomized to 1 of 2 RCA fluids. Progress was monitored using a standard daily panel of acid-base and biochemical tests. Results: Forty-eight patients, 23 C18 and 25 C15, were recruited. In both groups, acidosis resolved within 36 h of institution of CRRT. By day 3, there were significant differences in serum [Na+], standard base excess and serum bicarbonate concentration, all being higher in the C18 group (p < 0.01). By day 5, the PaCO2 had also risen in the C18 group (p = 0.03). Conclusions: The C15 solution provided equivalent filter life to the C18 solution but without significant hypernatremia and metabolic alkalosis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherKarger
dc.relation.ispartofpagefrom194
dc.relation.ispartofpageto201
dc.relation.ispartofissue3
dc.relation.ispartofjournalBlood Purification
dc.relation.ispartofvolume42
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsHematology
dc.subject.keywordsUrology & Nephrology
dc.subject.keywordsRegional citrate anticoagulation
dc.titleA comparison between two dilute citrate solutions (15 vs. 18 mmol/l) in continuous renal replacement therapy: The base excess and renal substitution solution study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAnstey, C; Campbell, V; Richardson, A, A comparison between two dilute citrate solutions (15 vs. 18 mmol/l) in continuous renal replacement therapy: The base excess and renal substitution solution study, Blood Purification, 2016, 42 (3), pp. 194-201
dcterms.dateAccepted2016-05-17
dc.date.updated2021-09-02T03:21:39Z
gro.hasfulltextNo Full Text
gro.griffith.authorAnstey, Christopher


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