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dc.contributor.authorHewson, Chris
dc.contributor.authorMorris, Kevin V
dc.contributor.editorMorris, KV
dc.date.accessioned2021-09-07T01:52:49Z
dc.date.available2021-09-07T01:52:49Z
dc.date.issued2016
dc.identifier.isbn978-3-319-23906-4
dc.identifier.doi10.1007/82_2015_486
dc.identifier.urihttp://hdl.handle.net/10072/407699
dc.description.abstractThe recent discovery that long non-coding RNAs (lncRNAs) are functional and are not merely "transcriptional noise" has spawned an entirely new arena of investigation. LncRNAs have been found to be functional in the regulation of a wide variety of genes, including those involved in cancer. Studies have identified that lncRNAs play a role in the development and regulation of cancer and can also act as prognostic markers. Meanwhile, exosomes , which are extracellular particles generated endogenously by cells, have been observed to act as transport vesicles for a variety of biological components, particularly proteins and RNAs. This transportation of biological components has been shown to impact a variety of biological processes including the development of cancer. Collectively, these observations, along with those of several recent studies, suggest that lncRNAs and exosomes may function together to disseminate cell signals that alter and/or control local cellular microenvironments. This review will identify the various roles that lncRNAs and exosomes play in cancer development, as well as the possibility that exosomes may transfer functional lncRNAs between cells as a means of cell-to-cell communication.
dc.languageEnglish
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AG
dc.relation.ispartofbooktitleLong Non-coding RNAs in Human Disease
dc.relation.ispartofpagefrom41
dc.relation.ispartofpageto56
dc.relation.ispartofvolume394
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode3207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsGenetics & Heredity
dc.subject.keywordsHeat-Shock Proteins
dc.subject.keywordsMediated Transfer
dc.titleForm and Function of Exosome-Associated Long Non-coding RNAs in Cancer
dc.typeBook chapter
dcterms.bibliographicCitationHewson, C; Morris, KV, Form and Function of Exosome-Associated Long Non-coding RNAs in Cancer, Long Non-coding RNAs in Human Disease, 2016, 394, pp. 41-56
dc.date.updated2021-09-07T01:50:45Z
gro.hasfulltextNo Full Text
gro.griffith.authorMorris, Kevin V.


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